Bcl-2-IN-23
Bcl-2-IN-23 (compound 5) is a selective inhibitor targeting Bcl-2. The IC50 of Bcl-2-IN-23 in HTB-140, HeLa and SW620 cells is 25.7-33.7 μM. Bcl-2-IN-23 can non-covalently competitively bind to Bcl-2 protein, significantly reduce its expression, and induce late apoptosis and necroptosis of cancer cells. Bcl-2-IN-23 enhances the sensitivity of cancer cells to apoptosis and reduces the release of IL-6 inflammatory factors by disrupting the Bcl-2-mediated mitochondrial apoptosis inhibition pathway. Bcl-2-IN-23 can be used for anti-apoptosis research of malignant tumors such as melanoma, cervical cancer, and colorectal cancer.
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- Formule: C32H32N10O2
- Masse moléculaire:588.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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Bcl-2 |
Parmacokinetics
| Species | Dose | Route | Note | T1/2 (Elimination) | T1/2 (Distribution) |
|---|---|---|---|---|---|
| Mice | 1 mg/kg | i.v. | d | 1 L/h | / |
| Mice | 12 mg/kg | i.v. | 4 | / | 1 h |
Chemical Information
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Masse moléculaire 588.66
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Formule C32H32N10O2
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SMILES
COC1=CC(C2=CC=C(NC3=NN=NN3CCC4=CC=CC=C4)C(OC)=C2)=CC=C1NC5=NN=NN5CCC6=CC=CC=C6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bcl-2-IN-23 Related Classifications
HY-176219 Related Classifications
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