2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Icapamespib

Icapamespib  (Synonyms: PU-HZ151)

Cat. No.: HY-137441 Purity: 99.52%
COA Handling Instructions

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Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5 nM. Icapamespib is able to cross blood-brain barrier.

For research use only. We do not sell to patients.

Icapamespib Chemical Structure

Icapamespib Chemical Structure

CAS No. : 1000999-96-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 495 In-stock
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Icapamespib Related Antibodies

Top Publications Citing Use of Products

View All HSP Isoform Specific Products:

View All Isoforms
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5 nM. Icapamespib is able to cross blood-brain barrier[1].

Clinical Trial
Molecular Weight

526.39

Formula

C19H23IN6O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

IC1=C(SC2=NC3=C(N)N=CN=C3N2CCNCC(C)(C)C)C=C4OCOC4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (189.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8997 mL 9.4987 mL 18.9973 mL
5 mM 0.3799 mL 1.8997 mL 3.7995 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.52%

COA (255 KB) HNMR (264 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8997 mL 9.4987 mL 18.9973 mL 47.4933 mL
5 mM 0.3799 mL 1.8997 mL 3.7995 mL 9.4987 mL
10 mM 0.1900 mL 0.9499 mL 1.8997 mL 4.7493 mL
15 mM 0.1266 mL 0.6332 mL 1.2665 mL 3.1662 mL
20 mM 0.0950 mL 0.4749 mL 0.9499 mL 2.3747 mL
25 mM 0.0760 mL 0.3799 mL 0.7599 mL 1.8997 mL
30 mM 0.0633 mL 0.3166 mL 0.6332 mL 1.5831 mL
40 mM 0.0475 mL 0.2375 mL 0.4749 mL 1.1873 mL
50 mM 0.0380 mL 0.1900 mL 0.3799 mL 0.9499 mL
60 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7916 mL
80 mM 0.0237 mL 0.1187 mL 0.2375 mL 0.5937 mL
100 mM 0.0190 mL 0.0950 mL 0.1900 mL 0.4749 mL
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Icapamespib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icapamespib1000999-96-1PU-HZ151HSPHeat shock proteinsInhibitorinhibitorinhibit

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