NU6310
NU6310 is a non-covalent, ATP-competitive CDK2 inhibitor with an IC50 of 0.16 μM against CDK2. NU6310 can be used for research on cell cycle regulation related to tumors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1453215-59-2
- Formel: C20H25N5O3S
- Molecular Weight:415.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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CDK2 0.16 μM (IC50) |
NU6310 is a non-covalent, ATP-competitive inhibitor that inhibits the kinase activity of purified CDK2, with an IC50 of 0.16 μM[1].
NU6310 (39-10000 nM; 30-240 seconds) binds reversibly to immobilized CDK2/cyclin A, with a KD of 0.716 μM[2].
NU6310 (overnight incubation) exerts no covalent modification effect on CDK2/cyclin A; it can be completely removed via dialysis, thereby restoring CDK2's kinase activity for the phosphorylation of the Rb protein[2].
NU6310 (50 μM; 1 hour) inhibits the phosphorylation of the Rb protein at the Thr821 site in SKUT-1B cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1453215-59-2
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Molecular Weight 415.51
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Formel C20H25N5O3S
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SMILES
O=S(C1=CC=C(NC2=NC3=C(C(OCC4CCCCC4)=N2)NC=N3)C=C1)(CC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NU6310 Related Classifications
HY-182605 Related Classifications
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