1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV-2 Mpro-IN-2

SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies.

For research use only. We do not sell to patients.

SARS-CoV-2 Mpro-IN-2 Chemical Structure

SARS-CoV-2 Mpro-IN-2 Chemical Structure

CAS No. : 2768834-39-3

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Description

SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies[1].

IC50 & Target[1]

Mpro

0.40 μM (IC50)

In Vitro

SARS-CoV-2 Mpro-IN-2 (0.01-100 μM; 4 h) shows low cytotoxicity in Vero E6 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Vero E6 cells
Concentration: 0.01-100 μM
Incubation Time: 4 h
Result: Exhibited low cytotoxicity with a CC50 value of more than 100 μM.
In Vivo

SARS-CoV-2 Mpro-IN-2 (2 mg/kg; i.v.; single) exhibits clearance rate (CL), mean residence time (MRT), and half-life (t1/2) are 3140 mL/h/kg, 0.40 h, and 0.36 h, respectively[1].
SARS-CoV-2 Mpro-IN-2 (10 mg/kg; p.o.; single) is rapidly absorbed, with a time-to-maximum concentration (Tmax) of 0.5 h, and shows a moderate pharmacokinetic profile including a favorable t1/2 (1.73 h), a maximum concentration (Cmax) 74.6 ng/mL, and an area under curve (AUC0-t) of 235 ng h/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1].
Dosage: 2 mg/kg (for i.v.); 10 mg/kg (for p.o.).
Administration: Intravenous injection or oral administration; single.
Result: 1.19 Pharmacokinetic Parameters of SARS-CoV-2 Mpro-IN-2 in Male Sprague-Dawley rats[1].
IV (2 mg/kg) PO (10 mg/kg)
t1/2 (h) 0.36 1.73
Tmax (h) 0.08 0.5
Cmax (ng/mL) 1310 74.6
C0 (ng/mL) 1760 -
AUC0-t (ng/mL•h) 627 235
AUC0-∞ (ng/mL•h) 637 230
MRT0-∞ (h) 0.40 2.45
CL (mL/h/kg) 3140 -
F (%) - 7.2
Molecular Weight

475.39

Formula

C22H20Cl2N4O2S

CAS No.
SMILES

O=C(C1=CN=CC=C1)N2C[C@@H](C(NCC3=CC=CS3)=O)N(C4=CC(Cl)=C(C=C4)Cl)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SARS-CoV-2 Mpro-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SARS-CoV-2 Mpro-IN-2
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HY-151482
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