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Cat. No.: HY-123531

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JNJ 10329670

JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a K_i value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation.

For research use only. We do not sell to patients.

CAS No.: 400797-24-2
Formula: C₃₀H₃₄ClF₃N₆O₃S
Molecular Weight:651.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

JNJ 10329670 Chemical Structure

CAS No.: 400797-24-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

cathepsin S

34 nM (Ki)

All Cathepsin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
JY	IC₅₀	0.8 nM Compound: 50 (JNJ-10329670)	Inhibitory concentration against Ii degradation in human JY cells (range IC50 = 0.6-0.8 uM) Inhibitory concentration against Ii degradation in human JY cells (range IC50 = 0.6-0.8 uM)	[PMID: 15745822]

In Vitro

JNJ 10329670 (0-100 μM) inhibits cathepsin S and thereby block the proteolysis of the invariant chain in human B cell lines^[1].
JNJ 10329670 (0-10 μM) blocks proliferation of T cells in response to both antigens, but less so to the nonspecific T cell mitogen phytohemagglutinin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 400797-24-2
Molecular Weight 651.14
Formula C₃₀H₃₄ClF₃N₆O₃S
SMILES

FC(F)(F)C1=CC=C(C=C1)C2=NN(C3=C2CN(CC3)S(=O)(C)=O)CCCN4CCC(CC4)N5C6=CC(Cl)=CC=C6N(C5=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thurmond RL, et, al. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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JNJ 10329670

All Cathepsin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNJ 10329670 Related Classifications

HY-123531 Related Classifications