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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
237 Results for "
protein hydrolase
" in MedChemExpress (MCE) Product Catalog:
Products (237)
237 Results for "protein hydrolase" in MCE Product Catalog:
9
9 Publications Verification
Synonyms: CRA 024781; PCI-24781
Abexinostat (CRA 024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM. Abexinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM .
9
Target:
Research Areas:
Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM .
3
Research Areas:
Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets .
2
2 Cited Publications
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:
Research Areas:
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
2
2 Cited Publications
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:
Research Areas:
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
1
1 Cited Publications
Target:
Research Areas:
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM) .
1
1 Cited Publications
Cat. No.: HY-P75903
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KYNU; Kynureninase (L-Kynurenine hydrolase); Kynureninase; Uncharacterized protein KYNU; L-Kynurenine hydrolase; KYNUU; Abnormal Fluorescence Under UV Illumination; VCRL2
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P700729
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GGT1; GGT 1; Prev. GGT; Gamma-Glutamyltranspeptidase; D22S732; Gamma-Glutamyltransferase; D22S672; Glutathione hydrolase; CD224; CD224 Antigen; Glutathione hydrolase 1 Proenzyme; GGT1 protein; Gamma-Glutamyltranspeptidase 1; GGTD; Leukotriene-C4 hydrolase
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71230
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPT1; INCL; Prev. PPT; Ceroid-Lipofuscinosis, Neuronal 1, Infantile; CLN1; PPT-1; Palmitoyl-protein hydrolase 1; Palmitoyl-protein Thioesterase 1; Ceroid-Palmitoyl-Palmitoyl-protein Thioesterase 1
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P700622
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPT1; INCL; Prev. PPT; Ceroid-Lipofuscinosis, Neuronal 1, Infantile; CLN1; PPT-1; Palmitoyl-protein hydrolase 1; Palmitoyl-protein Thioesterase 1; Ceroid-Palmitoyl-Palmitoyl-protein Thioesterase 1
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P701447
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP28; Ubiquitin Specific Peptidase 28; Ubiquitin-Specific-Processing Protease 28; Ubiquitin Carboxyl-Terminal hydrolase 28; Deubiquitinating Enzyme 28; Ubiquitin Thioesterase 28; KIAA1515; Ubiquitin Carboxyl-Terminal hydrolase; Ubiquitin Specific Proteas
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P702063
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: USP11; Ubiquitin Specific Peptidase 11; UHX1; Ubiquitin Carboxyl-Terminal hydrolase 11; Deubiquitinating Enzyme 11; Ubiquitin Thioesterase 11; Ubiquitin Carboxyl-Terminal hydrolase, X-Linked; Ubiquitin-Specific Processing Protease 11; Ubiquitin-Specific-P
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P77083
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MEP1A; Meprin A, Alpha (PABA Peptide hydrolase); Meprin A Subunit Alpha; PPH Alpha; PABA Peptide hydrolase; BA268F1.1 (Meprin A Alpha (PABA Peptide hydrolase)); Endopeptidase-2; Metalloendopeptidase; PPHA; Meprin A Subunit; N-Benzoyl-L-Tyrosyl-P-Amino-Ben
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71115
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UCHL3; Ubiquitin C-Terminal hydrolase L3; Ubiquitin Carboxyl-Terminal Esterase L3 (Ubiquitin Thiolesterase); Ubiquitin Carboxyl-Terminal hydrolase Isozyme L3; Ubiquitin Thioesterase L3; Ubiquitin Thiolesterase; UCH-L3; Ubiquitin Carboxyl-Terminal Hydrolas
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P703232
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP4; Ubiquitin Specific Peptidase 4; UNP; Unph; Ubiquitin Specific Peptidase 4 (Proto-Oncogene); Ubiquitin Carboxyl-Terminal hydrolase 4; Ubiquitous Nuclear protein Homolog; Deubiquitinating Enzyme 4; Ubiquitin Thioesterase 4; Ubiquitin Specific Protease
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P79357
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NOTUM; HNOTUM; Notum, Palmitoleoyl-protein Carboxylesterase; Notum Pectinacetylesterase Homolog (Drosophila); [Wnt protein] O-Palmitoleoyl-L-Serine hydrolase; Notum Pectinacetylesterase Homolog; Palmitoleoyl-protein Carboxylesterase NOTUM; protein Notum H
Species:
Human
Source:
CHO
1
1 Cited Publications
Cat. No.: HY-P71418
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP14; Ubiquitin Specific Peptidase 14; TGT; Ubp6; Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase); Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase); Ubiquitin Carboxyl-Terminal hydrolase 14; Deubiquitinating Enzyme 14; Ubiqu
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P702603
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-Processing Protease 7; Ubiquitin Carboxyl-Terminal hydrolase 7; Deubiquitinating Enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74478
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-Processing Protease 7; Ubiquitin Carboxyl-Terminal hydrolase 7; Deubiquitinating Enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701411
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP15; Ubiquitin Specific Peptidase 15; KIAA0529; UNPH4; Ubiquitin-Specific-Processing Protease 15; Ubiquitin Carboxyl-Terminal hydrolase 15; Deubiquitinating Enzyme 15; Ubiquitin Thioesterase 15; Ubiquitin Specific Protease 15; Ubiquitin Thiolesterase 15
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
