DNPH1 Antibody (YA5970)
(Synonyms: DNPH1; C6orf108; RCL; 5-hydroxymethyl-dUMP N-hydrolase ; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; c-Myc-responsive protein RCL; )DNPH1 Antibody (YA5970) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNPH1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:100-300 |
Product Details
DNPH1 Antibody (YA5970) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNPH1.
-
Host Rabbit
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 19 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
DNPH1 is a Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration[1].
-
Subcellular Localization
Cytoplasm; Nucleus
-
Expression
Tissue_specificity:Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers
Induction:Expression is induced by ETV1 -
Isoforms & Post-Translational Modification
O43598 has 2 isomers: O43598-1: 19108 Da (predicted); O43598-2: 16187 Da (predicted).
-
Subunit
Monomer and homodimer
-
SwissProt ID
-
Synonyms
DNPH1; C6orf108; RCL; 5-hydroxymethyl-dUMP N-hydrolase ; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; c-Myc-responsive protein RCL;
Documentation
Powered by Bioz
