GLO2/Glyoxalase II Protein, Human (GST)
GLO2, or Glyoxalase II Protein, serves as a thiolesterase, playing a crucial role in catalyzing the hydrolysis of S-D-lactoyl-glutathione. This activity generates glutathione and D-lactic acid, emphasizing GLO2's significance in cellular metabolism. The enzyme contributes to regulating glutathione levels and the conversion of substrates within cellular pathways. GLO2/Glyoxalase II Protein, Human (GST) is the recombinant human-derived GLO2/Glyoxalase II protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
GLO2, or Glyoxalase II Protein, serves as a thiolesterase, playing a crucial role in catalyzing the hydrolysis of S-D-lactoyl-glutathione. This activity generates glutathione and D-lactic acid, emphasizing GLO2's significance in cellular metabolism. The enzyme contributes to regulating glutathione levels and the conversion of substrates within cellular pathways. GLO2/Glyoxalase II Protein, Human (GST) is the recombinant human-derived GLO2/Glyoxalase II protein, expressed by E. coli , with N-GST labeled tag.
GLO2, also known as Glyoxalase II, functions as a thiolesterase, playing a pivotal role in catalyzing the hydrolysis of S-D-lactoyl-glutathione. This enzymatic activity results in the formation of glutathione and D-lactic acid. The specific role of GLO2 in this process underscores its importance in the cellular metabolism of S-D-lactoyl-glutathione, contributing to the regulation of glutathione levels and the conversion of substrates involved in cellular pathways.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
Q16775-1 (K50-D308)
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Molecular Construction
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N-term
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GST
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GLO2 (K50-D308)
Accession # Q16775-1 -
C-term
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Protein Length
Partial
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Synonyms
HAGH; GLXII; Hydroxyacylglutathione Hydrolase; Hydroxyacylglutathione Hydroxylase; HAGH1; Hydroxyacyl Glutathione Hydrolase; GLO2; Glx II; Hydroxyacylglutathione Hydrolase, Mitochondrial; GLO2D; Glyoxalase II; GLX2
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AA Sequence
KVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
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Predicted Molecular Mass
55.7 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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