HAGH - hydroxyacylglutathione hydrolase Gene

Homo sapiens

Also known as GLO2; GLX2; GLXII; HAGH1

Gene ID: 3029 | Gene type: protein coding

About HAGH

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,807,629-1,827,194 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 47.0), liver (RPKM 45.0) and 25 other tissues.

Summary

The Enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

HAGH Products(5)

mRNA	Protein	Name
NM_001040427.2	NP_001035517.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 2
NM_001286249.2	NP_001273178.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 3 precursor
NM_001363912.1	NP_001350841.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 4 precursor
NM_001363914.1	NP_001350843.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 5
NM_005326.6	NP_005317.2	hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor

HAGH Protein Structure

Lactamase_B

0
100
200
308 a.a.

Protein Preferred Names

Protein Names

hydroxyacylglutathione hydrolase, mitochondrial

glyoxalase II

Recombinant HAGH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71690	GLO2/Glyoxalase II Protein, Human (GST)	Q16775 (50K-308D)	≥95%

Related Diseases

Diseases

Alias

Hydroxyacyl Glutathione Hydrolase Deficiency

Glyoxalase Ii Deficiency

Triosephosphate Isomerase Deficiency

TPID	Triose Phosphate-Isomerase Deficiency
Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency	Tpi Deficiency
Triose Phosphate Isomerase Deficiency	Deficiency Of Phosphotriose Isomerase
Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy	EE
Epema Syndrome	Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Ethe1 Deficiency	Eme
Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05992	HAGH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HAGH	VGNC	VGNC:41585
Mus musculus	HAGH	MGD	MGI:95745
Bos taurus	HAGH	VGNC	VGNC:29742
Felis catus	HAGH	VGNC	VGNC:67533
Rattus norvegicus	HAGH	RGD	RGD:2779
Macaca mulatta	HAGH	VGNC	VGNC:73343
Others	HAGH	NCBI