CD38 Protein, Rabbit (HEK293, His)
Based on 1 Customer Validation
CD38 protein performs diverse functions, synthesizing cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion. It produces nicotinate-adenine dinucleotide phosphate (NAADP+), mobilizing calcium ions through 2'-phospho-cADPR and nicotinic acid, along with NADP+ and nicotinic acid. Additionally, CD38 acts as a cADPR hydrolase. CD38 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD38 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Rabbit
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CD38 protein performs diverse functions, synthesizing cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion. It produces nicotinate-adenine dinucleotide phosphate (NAADP+), mobilizing calcium ions through 2'-phospho-cADPR and nicotinic acid, along with NADP+ and nicotinic acid. Additionally, CD38 acts as a cADPR hydrolase. CD38 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD38 protein, expressed by HEK293 , with C-His labeled tag.
Background
The CD38 protein has multiple functions, including the synthesis of cyclic ADP-ribose (cADPR), a second messenger involved in glucose-induced insulin secretion. It is also responsible for producing nicotinate-adenine dinucleotide phosphate, NAADP(+), which mobilizes calcium ions, using 2'-phospho-cADPR and nicotinic acid, as well as NADP(+) and nicotinic acid. In addition, CD38 exhibits cADPR hydrolase activity.
Verified Bioactivity
Immobilized Human CD38 at 1 μg/mL (100 μL/well) can bind Anti-CD38 Antibody. The ED50 for this effect is 20.91 ng/mL.
Technical Parameters
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Species Rabbit
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Source HEK293
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Tag C-His
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Accession
Q9MZ03 (L43-M298)
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Molecular Construction
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N-term
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CD38 (L43-M298)
Accession # Q9MZ03 -
His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CD38; NAD(+) Nucleosidase; CD38 Molecule; CD38 Antigen (P45); ADP-Ribosyl Cyclase 1; ADPRC 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase; 2'-Phospho-Cyclic-ADP-Ribose Transferase; Cluster Of Di
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AA Sequence
LTWRQSSMGATDHVSAIVLGRCLTYTRNMHPELRNQDCKKILNTFTSAFVSKDPCNITKEDYQPLIDLVTQTVPCNKTLFWSRSKELAHQYSGIQKEMFTLEDTLLGYIADNLVWCGDPRTSEVKEEFCPYRNENCSSTATSVFWTVVSQKFAESACGTVYVMLNGSRTTAFSKASTFGSVEVFNLHPDRVHTLHAWVMHDIGGVERDSCLGSSIKELKSIVNQRNISFFCQDDYRPARFVQCVRHPEHPSCSVLM
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Molecular Weight
Approximately 37-46 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, PH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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