CD38 Protein, Rabbit (HEK293, His)

CD38 protein performs diverse functions, synthesizing cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion. It produces nicotinate-adenine dinucleotide phosphate (NAADP+), mobilizing calcium ions through 2'-phospho-cADPR and nicotinic acid, along with NADP+ and nicotinic acid. Additionally, CD38 acts as a cADPR hydrolase. CD38 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD38 protein, expressed by HEK293 , with C-His labeled tag.

The CD38 protein has multiple functions, including the synthesis of cyclic ADP-ribose (cADPR), a second messenger involved in glucose-induced insulin secretion. It is also responsible for producing nicotinate-adenine dinucleotide phosphate, NAADP(+), which mobilizes calcium ions, using 2'-phospho-cADPR and nicotinic acid, as well as NADP(+) and nicotinic acid. In addition, CD38 exhibits cADPR hydrolase activity.

Immobilized Human CD38 at 1 μg/mL (100 μL/well) can bind Anti-CD38 Antibody. The ED₅₀ for this effect is 20.91 ng/mL.

Rabbit

HEK293

C-His

Q9MZ03 (L43-M298)

100009409  [NCBI]

Extracellular Domain

LTWRQSSMGATDHVSAIVLGRCLTYTRNMHPELRNQDCKKILNTFTSAFVSKDPCNITKEDYQPLIDLVTQTVPCNKTLFWSRSKELAHQYSGIQKEMFTLEDTLLGYIADNLVWCGDPRTSEVKEEFCPYRNENCSSTATSVFWTVVSQKFAESACGTVYVMLNGSRTTAFSKASTFGSVEVFNLHPDRVHTLHAWVMHDIGGVERDSCLGSSIKELKSIVNQRNISFFCQDDYRPARFVQCVRHPEHPSCSVLM

33-49 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, PH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.