Carboxylesterase 1 Protein, Human (549a.a, HEK293, His)

Carboxylesterase 1 is an enzyme involved in the detoxification of xenobiotics and the activation of ester and amide prodrugs. It hydrolyzes aromatic and aliphatic esters but exhibits no catalytic activity toward amides or fatty acyl-CoA esters. This enzyme hydrolyzes the methyl ester group of cocaine to form benzoylecgonine and catalyzes the transesterification of cocaine to produce cocaethylene. Additionally, Carboxylesterase 1 demonstrates fatty acid ethyl ester synthase activity, esterifying oleic acid to form ethyloleate, and hydrolyzes monoacylglycerides into free fatty acids and glycerol. It also hydrolyzes 2-arachidonoylglycerol and prostaglandins, and converts cellular cholesteryl esters to free cholesterol, promoting reverse cholesterol transport (RCT). Specifically, it facilitates free cholesterol efflux from macrophages to extracellular acceptors and releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into bile. by similar: Its functions also include critical roles in cholesterol metabolism and drug metabolism pathways.