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Results for "

acetylcholinesterase inhibitor

" in MedChemExpress (MCE) Product Catalog:

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299

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

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Natural
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Isotope-Labeled Compounds

Oligonucleotides

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-N0342

Scopoletin 4 Publications Verification Gelseminic acid; Chrysatropic acid	Cholinesterase (ChE) Apoptosis	Inflammation/Immunology
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-76299

Galanthamine Maximum Cited Publications 15 Publications Verification Galantamine	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N0810

Timosaponin AIII 2 Publications Verification	Cholinesterase (ChE)	Neurological Disease Cancer
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

HY-N0825

Nodakenin	Cholinesterase (ChE)	Inflammation/Immunology
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-B1315

Carbaryl	Environmental Pollutants Apoptosis Insecticide Cholinesterase (ChE) Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Carbaryl is the inhibitor for *acetylcholinesterase* that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide .

HY-W017423

(-)-Carvone	Environmental Pollutants Cholinesterase (ChE)	Neurological Disease
(-)-Carvone is an insect neurotoxin and a irreversible *acetylcholinesterase* (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-N0793

Protopine Corydinine	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of *acetylcholinesterase*. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-Y0504

Trimethylammonium chloride Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride	Environmental Pollutants Cholinesterase (ChE) Endogenous Metabolite	Metabolic Disease
Trimethylammonium chloride (Hegzadesil) is a non-competitive *Acetylcholinesterase* inhibitor. Trimethylammonium chloride reversibly blocks the deacetylation of acetylcholinesterase .

HY-B0832

Profenofos 1 Publications Verification	Environmental Pollutants Cholinesterase (ChE) Insecticide	Neurological Disease
Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase	Infection Neurological Disease
Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC₅₀ values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity .

HY-N6895

Violanthin	Cholinesterase (ChE)	Inflammation/Immunology
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 79.80 μM .

HY-N1089

Vincosamide	Cholinesterase (ChE)	Inflammation/Immunology
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the *acetylcholinesterase* (AChE) activity with anti-inflammatory activity .

HY-N4261

Dehydronuciferine	Cholinesterase (ChE)	Metabolic Disease
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-76299R

Galanthamine (Standard) Galantamine (Standard)	Reference Standards Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-W020785

Fosthiazate	Environmental Pollutants Cholinesterase (ChE)	Others
Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .

HY-N1474

Picfeltarraenin IA	Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-116792

Phenoxyacetone Phenoxy-2-propanone	Cholinesterase (ChE)	Others
Phenoxyacetone is a competitive acetylcholinesterase (AChE) inhibitor .

HY-21629

N-Boc-4-piperidinemethanol	Cholinesterase (ChE) Drug Intermediate	Others
N-Boc-4-piperidinemethanol (Compound 4) is a synthetic intermediate. N-Boc-4-piperidinemethanol can be used for the preparation of *Acetylcholinesterase* inhibitors .

HY-17541A

Cysteine Protease inhibitor hydrochloride 3 Publications Verification	Cholinesterase (ChE) Cathepsin	Neurological Disease
Cysteine Protease inhibitor hydrochloride, an inhibitor of Cysteine Protease, binds to acetylcholinesterase (AChE). Cysteine Protease inhibitor hydrochloride is applicable to the research of Alzheimer's disease .

HY-N0342R

Scopoletin (Standard) Gelseminic acid (Standard); Chrysatropic acid (Standard)	Reference Standards Cholinesterase (ChE) Apoptosis	Inflammation/Immunology
Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-B1093

Fenchlorphos 1 Publications Verification	Environmental Pollutants Parasite Cholinesterase (ChE)	Infection
Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction .

HY-W278867

trans-3,5-Dimethoxystilbene trans-Pinosylvin dimethyl ether	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an *acetylcholinesterase* inhibitor with a IC₅₀ of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-126765

Territrem B	Cholinesterase (ChE)	Infection Neurological Disease
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus .

HY-110389

Pitofenone hydrochloride	Cholinesterase (ChE)	Neurological Disease
Pitofenone hydrochloride, a spasmolytic compound, inhibits the *acetylcholinesterase* (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-W127493

1-Hexacosanol Ceryl Alcohol	Biochemical Assay Reagents	Infection
1-Hexacosanol can be used as an inhibitor of acetylcholinesterase (AChE). 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

HY-Y0504R

Trimethylammonium chloride (Standard) Hegzadesil (Standard); Trimethylamine hydrochloric acid (Standard); Trimethylamine monohydrochloride (Standard)	Endogenous Metabolite Cholinesterase (ChE) Reference Standards	Metabolic Disease
Trimethylammonium chloride (Standard) is the analytical standard of Trimethylammonium chloride. This product is intended for research and analytical applications. Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase .

HY-B0884

Minaprine	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Minaprine is a brain-penetrant monoamine oxidase inhibitor. Minaprine also weakly inhibits *acetylcholinesterase* (AChE) activity. Minaprine reduces intraneuronal dopamine metabolism, lowers striatal homovanillic acid and dihydroxyphenylacetic acid levels, and raises striatal 3-methoxytyramine and 5-hydroxytryptamine levels. Minaprine exhibits convulsant, antidepressant properties .

HY-P5797

Fasciculin-II Fas-2	Cholinesterase (ChE)	Neurological Disease
Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE) .

HY-116026

3-Hydroxycarbofuran	Drug Metabolite Cholinesterase (ChE)	Neurological Disease
3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor .

HY-134137

Donepezil N-oxide	Cholinesterase (ChE) Drug Metabolite	Neurological Disease
Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor .

HY-W077226

AChE-IN-23	Cholinesterase (ChE)	Neurological Disease
AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM .

HY-114899

Azamethiphos	Environmental Pollutants Cholinesterase (ChE) Insecticide	Infection Neurological Disease
Azamethiphos is an *acetylcholinesterase* inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .

HY-106440

Zifrosilone	Cholinesterase (ChE)	Neurological Disease
Zifrosilone is an orally active acetylcholinesterase (AChE) inhibitor with a mean maximum inhibition of 20.9% at 10 mg. Zifrosilone can be used for the research of neurological disease .

HY-76299S

Galanthamine-d6	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine-d₆ (Galantamine-d₆) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-119292

AP2238	Cholinesterase (ChE) Amyloid-β	Neurological Disease
AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with K_i values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease .

HY-155750

AChE-IN-37	Cholinesterase (ChE)	Neurological Disease
AChE-IN-37 (compound A2) is anacetylcholinesterase inhibitorswith an IC₅₀ of 0.23 μM. AChE-IN-37 effects ROS levels and gene expression of NRF2 .

HY-N6619A

Lycoramine	Cholinesterase (ChE)	Neurological Disease
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-131413

O-Desmethyl Galanthamine Sanguinine	Cholinesterase (ChE)	Neurological Disease
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM .

HY-120479

Cythioate	Cholinesterase (ChE)	Neurological Disease
Cythioate is an organophosphorous insecticide and anthelmintic. Cythioate is an *acetylcholinesterase* inhibitor which interferes with neuromuscular transmission in ectoparastites .

HY-N8414

Dehydrogeijerin	Cholinesterase (ChE)	Neurological Disease
Dehydrogeijerin is an inhibitor of *acetylcholinesterase* with an IC₅₀ of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease .

HY-W049335

6,9-Dichloro-1,2,3,4-tetrahydroacridine	Drug Intermediate Cholinesterase (ChE)	Neurological Disease
6,9-Dichloro-1,2,3,4-tetrahydroacridine (compound 26) is an intermediate for the synthesis of acetylcholinesterase (AChE) inhibitors, which can be used in the study of Alzheimer's disease .

HY-150728

AChE-IN-22	Cholinesterase (ChE)	Neurological Disease
AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC₅₀ values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease .

HY-N12361

Osmanthuside B	Cholinesterase (ChE)	Neurological Disease
Osmanthuside B can be isolated from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb and has weak acetylcholinesterase inhibitory activity .

HY-155749

AChE-IN-36	Cholinesterase (ChE)	Neurological Disease
AChE-IN-36 (compound A4) is anacetylcholinesterase inhibitorswith an IC₅₀ of 0.04 μM. AChE-IN-36 effects ROS levels and gene expression of NRF2 .

HY-N10209

Paecilomide	Cholinesterase (ChE)	Others
Paecilomide is a pyridone alkaloid and *acetylcholinesterase* inhibitor .

HY-N15452

Eseramine	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
Eseramine is a weak *acetylcholinesterase* inhibitor with an IC₅₀ value of 9300 nM. Eseramine is promising for research of diseases involving the regulation of acetylcholinesterase, such as glaucoma, myasthenia gravis, and protection against organophosphate poisoning .

HY-W782096

Salvianolic acid H	Cholinesterase (ChE)	Cardiovascular Disease
Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor .

HY-N14533

Quinolactacin A2	Cholinesterase (ChE)	Infection
Quinolactacin A2 inhibits acetylcholinesterase and TNF production .

HY-134006

Stemoninine	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC₅₀=5.52 μM) .

HY-N13924

Arisugacin D	Cholinesterase (ChE)	Neurological Disease
Arisugacin D is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 3.5 μM .

Art. -Nr.	Produktname	Type

HY-D0837

Imidazole

2 Publications Verification

Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Biochemical Assay Reagents

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-21629

N-Boc-4-piperidinemethanol	Biochemical Assay Reagents
N-Boc-4-piperidinemethanol (Compound 4) is a synthetic intermediate. N-Boc-4-piperidinemethanol can be used for the preparation of *Acetylcholinesterase* inhibitors .

HY-W127493

1-Hexacosanol Ceryl Alcohol	Biochemical Assay Reagents
1-Hexacosanol can be used as an inhibitor of acetylcholinesterase (AChE). 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

HY-D0837R

Imidazole (Standard)

Glyoxaline (Standard); 1,3-Diaza-2,4-cyclopentadiene (Standard)

Biochemical Assay Reagents

Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-W127493R

1-Hexacosanol (Standard)

Ceryl Alcohol (Standard)

Biochemical Assay Reagents

1-Hexacosanol (Standard) is the analytical standard of 1-Hexacosanol. This product is intended for research and analytical applications. 1-Hexacosanol can be used as an inhibitor of acetylcholinesterase (AChE). 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects.

Art. -Nr.	Produktname	Target	Research Area

HY-P5797

Fasciculin-II Fas-2	Cholinesterase (ChE)	Neurological Disease
Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE) .

HY-P5798

Fasciculin-I FAS-I	Cholinesterase (ChE)	Neurological Disease
Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting *acetylcholinesterase* (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-N0342

Scopoletin 4 Publications Verification Gelseminic acid; Chrysatropic acid	Classification of Application Fields Coumarins Plants Monophenols Leguminosae Rubiaceae Phenols Phenylpropanoids Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Hedyotis diffusa Willd. Source Classification	Cholinesterase (ChE) Apoptosis
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-76299

Galanthamine Maximum Cited Publications 15 Publications Verification Galantamine	Alkaloids other families Other Alkaloids Plants Source Classification	Cholinesterase (ChE) Apoptosis
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N0528

Linarin 4 Publications Verification Buddleoside; Linarine	Flavonoids Flavones Labiatae Erythrina poeppigiana Plants Source Classification	TNF Receptor Cholinesterase (ChE) PKA Apoptosis Bacterial HIV Influenza Virus
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer .

HY-N6608

Physostigmine 2 Publications Verification Eserine	Alkaloids Lablab purpureus (L.) Sweet Leguminosae Plants Indole Alkaloids Source Classification	Cholinesterase (ChE)
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-N0810

Timosaponin AIII 2 Publications Verification	Liliaceae Neurological Disease Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids Source Classification Cancer	Cholinesterase (ChE)
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

HY-N0825

Nodakenin	Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Bidens parviflora Willd. Source Classification	Cholinesterase (ChE)
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-N0826

Corynoline 5+ Cited Publications	Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Cholinesterase (ChE) Keap1-Nrf2 Heme Oxygenase (HO) COX NO Synthase p38 MAPK JNK Apoptosis Bcl-2 Family Caspase STAT Interleukin Related
Corynoline is an orally active acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM. Corynoline exhibits multiple activities including anti-inflammatory, antinociceptive, antitumor and analgesic effects. Corynoline can be used in the research of diseases such as tumors and inflammatory pain .

HY-17387

(-)-Huperzine A 5+ Cited Publications Huperzine A	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Anti-aging Terpenoids Huperziaceae Sesquiterpenes Pyridine Alkaloids Huperzia serrata Plants Disease Research Fields	Cholinesterase (ChE) iGluR
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-N2081

Skimmianine 3 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-W017423

(-)-Carvone	Structural Classification Ketones, Aldehydes, Acids Gymnaster koraiensis Umbelliferae Plants Source Classification	Environmental Pollutants Cholinesterase (ChE)
(-)-Carvone is an insect neurotoxin and a irreversible *acetylcholinesterase* (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-N0793

Protopine Corydinine	Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification Cancer	Cholinesterase (ChE)
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of *acetylcholinesterase*. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N8290

Lactupicrin Lactucopicrin	Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Phenols Plants Compositae Source Classification	LOX-1 NF-κB Cholinesterase (ChE) Parasite
Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-N5077

Sinapine 2 Publications Verification	Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Cruciferae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) P-glycoprotein
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N2925

β-Amyrone 1 Publications Verification β-Amyron	Triterpenes Caprifoliaceae Plants Sambucus adnata Wall. ex DC. Source Classification	Fungal COX PPAR
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity .

HY-Y0504

Trimethylammonium chloride Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride	Structural Classification Natürliche Produkte Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Cholinesterase (ChE) Endogenous Metabolite
Trimethylammonium chloride (Hegzadesil) is a non-competitive *Acetylcholinesterase* inhibitor. Trimethylammonium chloride reversibly blocks the deacetylation of acetylcholinesterase .

HY-N0450

Sinapine thiocyanate 2 Publications Verification	Alkaloids Monophenols Classification of Application Fields Other Alkaloids Cruciferae Phenols Plants Disease Research Fields Source Classification Cancer	P-glycoprotein Cholinesterase (ChE)
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-17388

(±)-Huperzine A 1 Publications Verification	Structural Classification Terpenoids Huperziaceae Sesquiterpenes Huperzia serrata Plants Source Classification	Drug Isomer Cholinesterase (ChE) iGluR
(±)-Huperzine A is the racemate of (-)-Huperzine A (HY-17387). (-)-Huperzine A is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-N2511

Trimyristin	Structural Classification Classification of Application Fields Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields Lipid Source Classification	Cholinesterase (ChE) Phosphatase
Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC₅₀ values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity .

HY-N6895

Violanthin	Flavonoids other families Classification of Application Fields Flavones Orchidaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Dendrobium officinale Kimura et Migo Source Classification	Cholinesterase (ChE)
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 79.80 μM .

HY-N9386

Tellimagrandin II 1 Publications Verification Eugeniin	Classification of Application Fields Myriophyllum spicatum L. Phenols Polyphenols Haloragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Antibiotic
Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from ⁴C₁-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases .

HY-N4119

Neoeriocitrin	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	Phosphatase Cholinesterase (ChE) p38 MAPK Apoptosis Autophagy
Neoeriocitrin is a Naringin (HY-N0153) analogue found in Drynaria Rhizome. Neoeriocitrin induces cells proliferation, differentiation, up-regulates type I collagen, osteocalcin, and key osteogenic markers, and increases ALP activity. Neoeriocitrin increases expression of Runx2, COL I, OCN and Beclin1. Neoeriocitrin inhibits phosphorylation of P38 mitogen-activated protein kinase, reduces acetylcholinesterase (AChE) activity, and increases choline acetyltransferase (ChAT) activity. Neoeriocitrin reduces apoptosis and induces autophagy. Neoeriocitrin can be used for the researches of osteoporosis and Alzheimer's disease .

HY-N1089

Vincosamide	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Rubiaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids Source Classification	Cholinesterase (ChE)
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the *acetylcholinesterase* (AChE) activity with anti-inflammatory activity .

HY-N4261

Dehydronuciferine	Alkaloids other families Classification of Application Fields Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Source Classification	Cholinesterase (ChE)
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-76299R

Galanthamine (Standard) Galantamine (Standard)	Alkaloids Structural Classification other families Other Alkaloids Plants Source Classification	Reference Standards Cholinesterase (ChE) Apoptosis
Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N1474

Picfeltarraenin IA	Picria felterrae Lour. Infection Triterpenes Classification of Application Fields Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE)
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N0342R

Scopoletin (Standard) Gelseminic acid (Standard); Chrysatropic acid (Standard)	Structural Classification Monophenols Leguminosae Rubiaceae Coumarins Phenols Phenylpropanoids Plants Glycyrrhiza uralensis Fisch. Hedyotis diffusa Willd. Source Classification	Reference Standards Cholinesterase (ChE) Apoptosis
Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-W278867

trans-3,5-Dimethoxystilbene trans-Pinosylvin dimethyl ether	Structural Classification Stilbenes Classification of Application Fields Leguminosae Plants Inflammation/Immunology Disease Research Fields Astragalus membranaceus (Fisch.) Bunge Source Classification	Cholinesterase (ChE)
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an *acetylcholinesterase* inhibitor with a IC₅₀ of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-126765

Territrem B	Structural Classification Natürliche Produkte Marine natural products Marine microorganism Source Classification	Cholinesterase (ChE)
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus .

HY-N2211

Picfeltarraenin IB	Infection Triterpenes Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE)
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation .

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Source Classification	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of *acetylcholinesterase, activating α-secretase* and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .

HY-Y0504R

Trimethylammonium chloride (Standard) Hegzadesil (Standard); Trimethylamine hydrochloric acid (Standard); Trimethylamine monohydrochloride (Standard)	Structural Classification Natürliche Produkte Endogenous metabolite Source Classification	Endogenous Metabolite Cholinesterase (ChE) Reference Standards
Trimethylammonium chloride (Standard) is the analytical standard of Trimethylammonium chloride. This product is intended for research and analytical applications. Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase .

HY-N6894A

Pseudocoptisine chloride Isocoptisine chloride	Alkaloids Piperidine Alkaloids Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae Source Classification Corydalis turtschaninovii Bess.	Cholinesterase (ChE)
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects .

HY-N2043

Huperzine B	Lycopodiaceae Alkaloids Piperidine Alkaloids Lycopodium serratum Thunb． Pyridine Alkaloids Plants Source Classification	Cholinesterase (ChE)
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease .

HY-N6619A

Lycoramine	Alkaloids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	Cholinesterase (ChE)
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-131413

O-Desmethyl Galanthamine Sanguinine	Alkaloids Monophenols Cornaceae Phenols Cornus sanguinea Walter Plants Source Classification	Cholinesterase (ChE)
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM .

HY-N0825R

Nodakenin (Standard)	Structural Classification Coumarins Phenylpropanoids Umbelliferae Plants Bidens parviflora Willd. Source Classification	Reference Standards Cholinesterase (ChE)
Nodakenin (Standard) is the analytical standard of Nodakenin. This product is intended for research and analytical applications. Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-N7010

(-)-Corynoxidine	Infection Alkaloids Classification of Application Fields Corydalis speciosa Maxim. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Cholinesterase (ChE) Bacterial
(-)-Corynoxidine is an *acetylcholinesterase* inhibitor with an IC₅₀ value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa . (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees .

HY-N9928

Echinenone	Animals Ketones, Aldehydes, Acids Source Classification	Cholinesterase (ChE)
Echinenone is an acetylcholinesterase (AChE) inhibitor (IC₅₀=16.29 μg/mL) with anti-Aβ(25-35) activity. Echinenone can inhibit MDA content and increase superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities to cope with oxidative stress damage .

HY-N12581

Kuwanon U	Flavonoids Flavonones Morus alba L. Plants Moraceae Source Classification	Cholinesterase (ChE)
Kuwanon U is a potent *cholinesterase* inhibitor with IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .

HY-N2043R

Huperzine B (Standard)	Lycopodiaceae Alkaloids Piperidine Alkaloids Lycopodium serratum Thunb． Pyridine Alkaloids Plants Source Classification	Reference Standards Cholinesterase (ChE)
Huperzine B (Standard) is the analytical standard of Huperzine B. This product is intended for research and analytical applications. Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease .

HY-N8290R

Lactupicrin (Standard) Lactucopicrin (Standard)	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Phenols Plants Compositae Source Classification	Autophagy NF-κB AMPK Reference Standards
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-N5077R

Sinapine (Standard)	Alkaloids Structural Classification Monophenols Other Alkaloids Cruciferae Phenols Plants Source Classification	Reference Standards Cholinesterase (ChE) P-glycoprotein
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N0528R

Linarin (Standard) Buddleoside (Standard); Linarine (Standard)	Structural Classification Flavonoids Flavones Labiatae Erythrina poeppigiana Plants Source Classification	TNF Receptor Reference Standards Cholinesterase (ChE) PKA Apoptosis Bacterial HIV Influenza Virus
Linarin (Standard) is the analytical standard of Linarin. This product is intended for research and analytical applications. Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer.

HY-N9515

Diallyl tetrasulfide	Structural Classification Natürliche Produkte Allium sativum L. Plants Amaryllidaceae Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats . Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes . Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats . Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury .

HY-N2081R

Skimmianine (Standard)	Alkaloids Structural Classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Source Classification	Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N8414

Dehydrogeijerin	Structural Classification Euryops arabicus Steud. ex Jaub. & Spach Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Cholinesterase (ChE)
Dehydrogeijerin is an inhibitor of *acetylcholinesterase* with an IC₅₀ of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease .

HY-N12361

Osmanthuside B	Acanthaceae Phenols Polyphenols Plants Rhaponticum chinense (S. Moore) L. Martins & Hidalgo Source Classification	Cholinesterase (ChE)
Osmanthuside B can be isolated from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb and has weak acetylcholinesterase inhibitory activity .

HY-N10209

Paecilomide	Alkaloids Microorganisms Classification of Application Fields Other Diseases Pyridine Alkaloids Disease Research Fields Source Classification	Cholinesterase (ChE)
Paecilomide is a pyridone alkaloid and *acetylcholinesterase* inhibitor .

HY-N15452

Eseramine	Alkaloids Leguminosae Other Alkaloids Plants Physostigma venenosum Balf. Source Classification	Cholinesterase (ChE)
Eseramine is a weak *acetylcholinesterase* inhibitor with an IC₅₀ value of 9300 nM. Eseramine is promising for research of diseases involving the regulation of acetylcholinesterase, such as glaucoma, myasthenia gravis, and protection against organophosphate poisoning .

Art. -Nr.	Produktname	Chemical Structure

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-B1946S

Dimethoate-d6
Dimethoate-d₆ is the deuterium labeled Dimethoate. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active *acetylcholinesterase* inhibitor. Dimethoate induces reactive oxygen species (ROS). Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice .

HY-76299S

Galanthamine-d6
Galanthamine-d₆ (Galantamine-d₆) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-B1315S1

Carbaryl-d7
Carbaryl-d₇ is the deuterium labeled Carbaryl (HY-B1315). Carbaryl is the inhibitor for *acetylcholinesterase* that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide .

HY-N6608S

Physostigmine-d3
Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-B0882S

Edrophonium-d5 chloride

Edrophonium-d₅ chloride is the deuterium labeled Edrophonium chloride (HY-B0882). Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has K_i values of 0.2, 0.2, and 0.4 μM and IC₅₀ values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis .

HY-76299S1

Galanthamine-O-methyl-d3
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

HY-W004287S

Methyl tridecanoate-d25
Methyl tridecanoate-d₂₅ is the deuterium labeled Methyl tridecanoate. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE) .

HY-114899S

Azamethiphos-d6

Azamethiphos-d₆ is deuterated labeled Azamethiphos (HY-114899). Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .

HY-W585905

Trimethylammonium chloride-13C3
Trimethylammonium chloride- ¹³C₃ is a deuterated labeled Trimethylammonium chloride (HY-Y0504). Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase .

HY-W753485

Profenofos-d3
Profenofos-d₃ is the deuterium labeled Profenofos (HY-B0832). Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-B0732S

Itopride-d6 hydrochloride
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor .

HY-B1315S

Carbaryl-d3
Carbaryl-d₃ is the deuterium labeled Carbaryl (HY-B1315). Carbaryl is the inhibitor for *acetylcholinesterase* that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide . X

HY-W750404

(-)-Carvone-d4
(-)-Carvone-d₄ is the deuterium labeled (-)-Carvone (HY-W017423). (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-105853S

Pitofenone-d4
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-W077226S

AChE-IN-23-d10
AChE-IN-23-d₁₀ (4-Amino-Alpha-diethyl amino-o-cresol-d₁₀ (dihydrochloride)) is the deuterium labeled AChE-IN-23 (HY-W077226). AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM .

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-121467S1

Acotiamide-d4

Acotiamide-d₄ (Z-338 (free base)-d₄) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-W699983

Imidazole-15N2

Imidazole- ¹⁵N₂ (Glyoxaline- ¹⁵N₂) is ¹⁵N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-124920S

Methiocarb-d3

Methiocarb-d₃ is the deuterium labeled Methiocarb (HY-124920). Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals .

HY-B0828S

Triazophos-d5

Triazophos-d₅ (Hostathion 40EC-d₅) is the deuterium labeled Triazophos(HY-B0828) . Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

Art. -Nr.	Produktname		Classification

HY-N5139

Lecithins, egg 1 Publications Verification Lecithins, egg yolk; Belovo PL 85		Emulsifiers Liposomal Film-forming Agents Solubilizing Agents
Lecithins, egg (Lecithins, egg yolk; Belovo PL 85) is an orally active natural phospholipid mixture extracted from egg yolks . Lecithins, egg inhibits the activities of acetylcholinesterase (AChE) and angiotensin-converting enzyme (ACE). Lecithins, egg exhibits antibacterial, antioxidant and anti-inflammatory activities, and helps delay cellular senescence. Lecithins, egg enhances nerve conduction, improves memory and cognitive function, and exerts positive effects on delaying neurodegenerative diseases. Lecithins, egg promotes lipid absorption and alleviates diarrhea. Lecithins, egg acts as a high-efficiency drug carrier for the preparation of targeted drug delivery systems such as liposomes .

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