Gallamine
Gallamine is an allosteric, selective muscarinic M2 acetylcholine receptor antagonist (EC50: 130 nM for [3H]NMS dissociation from porcine muscarinic M2 receptors). Gallamine is also an acetylcholinesterase inhibitor (IC50s : 1070 μM, 1480 μM, 235 μM for EeAChE, hAChE, hBChE, respectively (in the absence of MeCN)). Gallamine increases free norepinephrine levels. Gallamine can be used as a muscle relaxant.
For research use only. We do not sell to patients.
- CAS No.: 153-76-4
- Formula: C24H45N3O3
- Molecular Weight:423.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mAChR2 130 nM (EC50) |
EeAChE 1070 μM (IC50) |
hAChE 1480 μM (IC50) |
Chemical Information
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CAS No. 153-76-4
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Molecular Weight 423.63
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Formula C24H45N3O3
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SMILES
CCN(CC)CCOC1=C(OCCN(CC)CC)C(OCCN(CC)CC)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Elsinghorst PW, et al. First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. J Med Chem. 2007 Nov 15;50(23):5685-95. [Content Brief]
[2]. Matsuki A, et al. Effect of gallamine on plasma cortisol and catecholamine levels in man. Can Anaesth Soc J. 1973 Jul;20(4):539-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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