2. GPCR/G Protein Neuronal Signaling
  3. mAChR Cholinesterase (ChE)
  4. Gallamine

Gallamine is an allosteric, selective muscarinic M2 acetylcholine receptor antagonist (EC50: 130 nM for [3H]NMS dissociation from porcine muscarinic M2 receptors). Gallamine is also an acetylcholinesterase inhibitor (IC50s : 1070 μM, 1480 μM, 235  μM for EeAChE, hAChE, hBChE, respectively (in the absence of MeCN)). Gallamine increases free norepinephrine levels. Gallamine can be used as a muscle relaxant.

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Gallamine

Gallamine Chemical Structure

CAS No. : 153-76-4

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Gallamine Related Antibodies

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Description

Gallamine is an allosteric, selective muscarinic M2 acetylcholine receptor antagonist (EC50: 130 nM for [3H]NMS dissociation from porcine muscarinic M2 receptors). Gallamine is also an acetylcholinesterase inhibitor (IC50s : 1070 μM, 1480 μM, 235  μM for EeAChE, hAChE, hBChE, respectively (in the absence of MeCN)). Gallamine increases free norepinephrine levels. Gallamine can be used as a muscle relaxant[1][2].

IC50 & Target[1]

mAChR2

130 nM (EC50)

EeAChE

1070 μM (IC50)

hAChE

1480 μM (IC50)

Molecular Weight

423.63

Formula

C24H45N3O3
CAS No.
SMILES

CCN(CC)CCOC1=C(OCCN(CC)CC)C(OCCN(CC)CC)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gallamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gallamine153-76-4mAChRCholinesterase (ChE)Muscarinic acetylcholine receptorInhibitorinhibitorinhibit

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