AChE/BuChE-IN-5
AChE/BuChE-IN-5 (compound 5a) is a dual target inhibitor. AChE/BuChE-IN-5 has excellent nanomolar inhibitory activity on acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=3.5 nM). AChE/BuChE-IN-5 can be used for Alzheimer's Disease research.
For research use only. We do not sell to patients.
- Formula: C19H14N4O
- Molecular Weight:314.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
AChE 46.9 nM (IC50) |
RatBuChE 3.5 nM (IC50) |
AChE/BuChE-IN-5 inhibits acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=46.9 nM) and shows better inhibitory effects than the known dual inhibitor Rivastigmine(HY-17368) in vivo animal model of AD disease[1]. AChE/BuChE-IN-5 has a higher BuChE selectivity than AChE, and the selectivity index (SI) is 0.07, indicating that it has a stronger inhibitory effect on BuChE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Wistar rats[1]
-
Dosage:1 mg/kg
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Reduced MDA levels, elevated GSH levels, β-amyloid protein levels and 8- OHdG levels on an animal model of rats pre-treated with lead acetate.
Reduced the expression level of caspase-3 and VEGF compared with the PbAc group.
Chemical Information
-
Molecular Weight 314.34
-
Formula C19H14N4O
-
SMILES
C1(NC2=NN=C(O2)C3=CC(C4=CC=CC=C4)=CN=C3)=CC=CC=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BuChE-IN-5 Related Classifications
HY-163537 Related Classifications
Powered by Bioz