AChE/BuChE-IN-5
AChE/BuChE-IN-5 (compound 5a) is a dual target inhibitor. AChE/BuChE-IN-5 has excellent nanomolar inhibitory activity on acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=3.5 nM). AChE/BuChE-IN-5 can be used for Alzheimer's Disease research.
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- Formule: C19H14N4O
- Masse moléculaire:314.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
AChE 46.9 nM (IC50) |
RatBuChE 3.5 nM (IC50) |
In Vitro
AChE/BuChE-IN-5 inhibits acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=46.9 nM) and shows better inhibitory effects than the known dual inhibitor Rivastigmine(HY-17368) in vivo animal model of AD disease[1]. AChE/BuChE-IN-5 has a higher BuChE selectivity than AChE, and the selectivity index (SI) is 0.07, indicating that it has a stronger inhibitory effect on BuChE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[1]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Reduced MDA levels, elevated GSH levels, β-amyloid protein levels and 8- OHdG levels on an animal model of rats pre-treated with lead acetate.
Reduced the expression level of caspase-3 and VEGF compared with the PbAc group.
Chemical Information
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Masse moléculaire 314.34
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Formule C19H14N4O
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SMILES
C1(NC2=NN=C(O2)C3=CC(C4=CC=CC=C4)=CN=C3)=CC=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BuChE-IN-5 Related Classifications
HY-163537 Related Classifications
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