AChE-IN-111
AChE-IN-111 is an acetylcholinesterase inhibitor with a IC50 of 0.37 μM. AChE-IN-111 scavenges various reactive oxygen and nitrogen species. AChE-IN-111 exhibits significant antioxidant potential and iron regulatory protein levels. AChE-IN-111 can be used for the research of Alzheimer's disease.
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- Formule: C26H26N4O7S
- Masse moléculaire:538.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
AChE-IN-111 (Compound 4q) (62.5 μg/mL) exhibits weak inhibitory activity against butyrylcholinesterase, with an inhibition rate of 33.6%[1].
AChE-IN-111 (10 μg/mL) exhibits potent in vitro antioxidant potential, with a total antioxidant capacity of 83.05 mg gallic acid/g and an IRP level of 123.4 μM[1].
AChE-IN-111 (10 μg/mL) exhibits in vitro antioxidant and free radical scavenging activities against DPPH, ABTS, NO, OH and H2O2 free radicals, with IC50 values of 11.38, 9.88, 14.45, 18.68 and 21.15 μM, respectively[1].
AChE-IN-111 exhibits CYP450 inhibitory activity, with inhibitory effects on CYP2C19, CYP2C9, and CYP3A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Masse moléculaire 538.57
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Formule C26H26N4O7S
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SMILES
CCS(=O)(OC1=CC(/C=N/NC(COC2=CC=C(C3=NC4=CC=CC=C4N3)C=C2OC)=O)=CC=C1OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-111 Related Classifications
HY-182332 Related Classifications
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