country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182332

Copy Link Print Information

AChE-IN-111

AChE-IN-111 is an acetylcholinesterase inhibitor with a IC₅₀ of 0.37 μM. AChE-IN-111 scavenges various reactive oxygen and nitrogen species. AChE-IN-111 exhibits significant antioxidant potential and iron regulatory protein levels. AChE-IN-111 can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₆N₄O₇S
Molecular Weight:538.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-111 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE-IN-111 (Compound 4q) (62.5 μg/mL) exhibits weak inhibitory activity against butyrylcholinesterase, with an inhibition rate of 33.6%^[1].
AChE-IN-111 (10 μg/mL) exhibits potent in vitro antioxidant potential, with a total antioxidant capacity of 83.05 mg gallic acid/g and an IRP level of 123.4 μM^[1].
AChE-IN-111 (10 μg/mL) exhibits in vitro antioxidant and free radical scavenging activities against DPPH, ABTS, NO, OH and H₂O₂ free radicals, with IC₅₀ values of 11.38, 9.88, 14.45, 18.68 and 21.15 μM, respectively^[1].
AChE-IN-111 exhibits CYP450 inhibitory activity, with inhibitory effects on CYP2C19, CYP2C9, and CYP3A4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 538.57
Formula C₂₆H₂₆N₄O₇S
SMILES

CCS(=O)(OC1=CC(/C=N/NC(COC2=CC=C(C3=NC4=CC=CC=C4N3)C=C2OC)=O)=CC=C1OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Omar MA, et al. New benzimidazole-alkanesulfonate conjugates as cholinesterase inhibitors with in vitro and in silico validation. Sci Rep. 2026;16(1):8946. Published 2026 Mar 12. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

AChE-IN-111

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AChE-IN-111 Related Classifications

HY-182332 Related Classifications