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Results for "

conjugation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ACSL Family (1) ADC Antibody (1) ADC Linker (58) ADC Payload (2) Amino Acid Derivatives (3) Amino acid Transporter (1) AMPK (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (25) Autophagy (4) Bacterial (11) Bcl-2 Family (8) Biochemical Assay Reagents (116) Caspase (8) Cathepsin (1) CD22 (1) Connective Peptide (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (5) DNA/RNA Synthesis (4) Drug Derivative (1) Drug Intermediate (5) Drug Metabolite (3) Drug-Linker Conjugates for ADC (12) E1/E2/E3 Enzyme (2) E3 Ligase Ligand-Linker Conjugates (7) EGFR (2) Endogenous Metabolite (25) Environmental Pollutants (1) Epigenetic Reader Domain (5) Factor Xa (1) Ferroptosis (2) FKBP (1) Fluorescent Dye (25) Folate Receptor (FR) (5) Fungal (1) FXR (8) G protein-coupled Bile Acid Receptor 1 (15) Glutathione Peroxidase (2) Glutathione S-transferase (1) HBV (2) Histamine Receptor (1) HIV (2) Insulin Receptor (1) Integrin (5) Interleukin Related (2) Isotope-Labeled Compounds (11) LDLR (2) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (4) Liposome (6) LPL Receptor (8) MDM-2/p53 (8) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Mitophagy (1) MMP (3) MOFs (1) Monoamine Oxidase (1) Neurotensin Receptor (1) NF-κB (9) P-glycoprotein (8) PARP (7) PD-1/PD-L1 (1) PDGFR (1) Photosensitizer (1) PKA (7) Pregnane X Receptor (PXR) (1) Prostaglandin Receptor (1) PROTAC Linkers (22) PROTAC-Linker Conjugates for PAC (1) PROTACs (5) RABV (2) Radionuclide-Drug Conjugates (RDCs) (21) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (9) Sigma Receptor (1) Small Interfering RNA (siRNA) (1) Tau Protein (2) TET Protein (2) TGF-beta/Smad (1) Toll-like Receptor (TLR) (2) Topoisomerase (4) Transmembrane Glycoprotein (1) UGT (1) VEGFR (2)
By Research Areas:	Cancer (133) Cardiovascular Disease (4) Endocrinology (1) Infection (8) Inflammation/Immunology (29) Metabolic Disease (26) Neurological Disease (20)
Click Chemistry:	ADC Synthesis (7) TCO (2) Labeling and Fluorescence Imaging (5) DBCO (14) PROTAC Synthesis (1) BCN (1) Azide (10) Tetrazine (5) Alkynes (24)
Oligonucleotides:	Fluorescent Lipids (2) Pegylated Lipids (4) Guanine Nucleotide (1) Aptamers (1) Nucleotide Analogs (2) siRNA drugs (1) Polymers (1) Adenine Nucleotide (1) Cholesterol (1) siRNAs (1)

350

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Click Chemistry

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GMP Molecules

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-W019543

Disuccinimidyl suberate Crosslinker 10+ Cited Publications	Biochemical Assay Reagents	Cancer
Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697

DSG Crosslinker 4 Publications Verification Disuccinimidyl glutarate	Biochemical Assay Reagents	Inflammation/Immunology
DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329

BS3 Crosslinker 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-118759

DSP Crosslinker 2 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329A

BS3 Crosslinker disodium 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-P1351

Angiopep-2-Cys	Biochemical Assay Reagents	Cancer
Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine. Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .

HY-44221

MAC glucuronide linker-1	ADC Linker	Cancer
MAC glucuronide linker-1 is a claevable ADC linker for antibody-agent-conjugations (ADCs) .

HY-128925

AMAS 1 Publications Verification	ADC Linker	Cancer
AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.

HY-P2341

Angiopep-2 hydrochloride 3 Publications Verification	LDLR	Cancer
Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .

HY-130088

Bis-PEG2-NHS ester	ADC Linker	Cancer
Bis-PEG2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).

HY-130087

Bis-PEG3-NHS ester	ADC Linker	Cancer
Bis-PEG3-NHS ester is a nonclaevable 3-unit PEG linker for antibody-agent-conjugation (ADC).

HY-148426

OSu-PEG4-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Others
OSu-PEG4-VC-PAB-MMAE involves in GDP-FAmP₄MMAE (Monomethylauristatin E) synthesis, which is for GDP label via site-specific conjugation .

HY-157977

DOTA-GA-maleimide	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) MMP	Cancer
DOTA-GA-maleimide is a bifunctional chelator with protein conjugation and radiometal chelation capabilities. DOTA-GA-maleimide forms stable complexes with ¹¹¹In and conjugates with proteins via maleimide chemistry. DOTA-GA-maleimide conjugates with LFn, enabling ¹¹¹In radiolabeling of LFn through direct or pre-labeling strategies. Radiolabeled LFn is applicable to MMP activity imaging studies. DOTA-GA-maleimide is used in cancer research .

HY-W539916

Azido-mono-amide-DOTA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Others
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.

HY-130107

Ald-Ph-NHS ester	ADC Linker	Cancer
Ald-Ph-NHS ester is a nonclaevable linker for antibody-agent-conjugation (ADC).

HY-151645

Alkyne-SNAP	ADC Linker	Others
Alkyne-SNAP (compound 3) is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation .

HY-151646

Alkyne-PEG5-SNAP Alkyne-PEG5-BG	ADC Linker	Others
Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group. Alkyne-PEG5-SNAP can alkyne conjugated benzylguanine (BG), the BG moiety reacts specifically and rapidly with SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality suitable for further conjugation . Alkyne-PEG5-SNAP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W410002

Pomalidomide-propargyl	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-propargyl contains an E3 ligand and a terminal alkyl group ready for click conjugation. Pomalidomide-propargyl is ready for conjugation to target proteins for PROTAC.

HY-151727

Norbornene-NHS	ADC Linker	Others
Norbornene-NHS is a norbornene-functionalized antibody-drug conjugate linker (ADC Linker) bearing an NHS ester, which is applicable for highly efficient and specific antibody conjugation reactions in ADC research and development. Norbornene-NHS also acts as an azide-group-containing click chemistry reagent, serving as a dienophile for copper-free click reaction conjugation .

HY-W678394

DOTA-Thiol	Biochemical Assay Reagents	Others
DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.

HY-151819

N3Ac-OPhOMe	ADC Linker	Others
N3Ac-OPhOMe is a click chemistry reagent containing azido and p-methoxyphenyl ester groups, which can be used for biomolecule conjugation and organic synthesis .

HY-118483

Benziodarone L-2329	Endogenous Metabolite	Endocrinology
Benziodarone is a potent inhibitor of S-arylglutathione transferase enzyme system. Benziodarone catalyzes BSP conjugation with GSH. Benziodarone inhibits biliary excretion of synthetic BSP-GSH conjugates .

HY-W019877

Sodium sulfate decahydrate	Environmental Pollutants Biochemical Assay Reagents	Metabolic Disease
Sodium sulfate decahydrate is a ubiquitous salt that reaches toxic concentrations due to mining and other industrial activities. Sodium sulfate can be used to enhance the conjugation of phenolic drugs with sulfate and to treat hypercalcemia .

HY-W016562S

Hippuric acid-d5 2-Benzamidoacetic acid-d₅	Endogenous Metabolite	Metabolic Disease
Hippuric acid-d₅ is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

HY-150224

GalNAc unconjugated/naked Fitusiran sodium	Small Interfering RNA (siRNA) Factor Xa	Others
GalNAc unconjugated/naked Fitusiran (sodium), an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia .

HY-130089

Bis-PEG1-NHS ester	ADC Linker	Cancer
Bis-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC).

HY-W782078

Butyne-DOTA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Others
Butyne-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA can be used for conjugation of peptides and radionuclides.

HY-175888

APL-1082 Mc-exo-EVC-Exatecan	Drug-Linker Conjugates for ADC	Cancer
APL-1082 is a drug-Linker conjugate that can be used for ADC synthesis. APL-1082 contains Exatecan (HY-13631) and Linker (HY-175929). APL-1082 reduces aggregation and hydrophobicity in Trastuzumab (HY-P9907) ADCs, enables production of high-DAR (10) ADCs with homogeneity and defined physicochemical properties. APL-1082 forms a Trastuzumab ADC with enhanced stability, showing greater DAR retention over time. APL-1082 can be used for the research of gastric cancer .

HY-145365

DGN549-L	Drug-Linker Conjugates for ADC	Cancer
DGN549-L is a DNA alkylator and can be utilized for antibody conjugation at lysine residues. DGN549-L can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W717779

4-Aminobutyl-DOTA	Biochemical Assay Reagents	Others
4-Aminobutyl-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA can be used for conjugation of peptides and radionuclides.

HY-W016562S1

Hippuric acid-d2 2-Benzamidoacetic acid-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Hippuric acid-d₂ is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

HY-A0074

DTPA-tetra (t-Bu ester) tetra-tBu-DTPA	Biochemical Assay Reagents	Others
DTPA-tetra (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. DTPA-tetra (t-Bu ester) can be used for conjugation of peptides and radionuclides.

HY-W1048851B

4-Arm-PEG10000-Maleimide 4-Arm-PEG10000-Mal	Biochemical Assay Reagents	Others
4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .

HY-151781

Fmoc-L-Dap(Poc)-OH	ADC Linker	Others
Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder) .

HY-151742

Norbornene-methyl-NHS	ADC Linker	Others
Norbornene-methyl-NHS is a norbornene-based antibody-drug conjugate linker (ADC Linker) bearing methyl and NHS ester functional groups, which can be used for specific antibody conjugation. Norbornene-methyl-NHS is also a click chemistry reagent containing a TCO group, acting as a dienophile for conjugation via the Diels-Alder reaction, namely the copper-free click reaction with tetrazine .

HY-157438

pppApA	Bacterial	Metabolic Disease
pppApA is a linear dinucleotide intermediate in the enzymatic production of the bacterial signalling nucleotide c-diAMP. pppApA is formed by conjugation between two molecules of ATP .

HY-130104

Ald-Ph-amido-PEG2-C2-NHS ester	ADC Linker	Cancer
Ald-Ph-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).

HY-130101

Ald-Ph-amido-PEG4-C2-NHS ester	ADC Linker	Cancer
Ald-Ph-amido-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC).

HY-W717830

CB-Cyclam	Biochemical Assay Reagents	Others
CB-Cyclamis a bifunctional chelator (Bifunctional Chelator; BFC), which is a main chain Cyclen derivative of the macrocyclic ligand tetradecane. CB-Cyclam can be used for conjugation of peptides and radionuclides.

HY-164785

TCO-PEG5-C2-Mal	Drug Intermediate	Others
TCO-PEG5-maleimide is a PEG linker with TCO and maleimide groups, specifically enabling tetrazine click chemistry and thiol conjugation for bioconjugation, probe design, and drug delivery.

HY-151697

DACN(Tos2)	ADC Linker	Others
DACN(Tos2) is a a click chemistry reagent containing an cycloalkynes group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. DACN(Tos2) through such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes. DACN(Tos2) can be used for the research of molecular conjugation .

HY-151795

DACN(Tos) hydrochloride	ADC Linker	Others
DACN(Tos) hydrochloride is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions, such strain-promoted azide-alkyne cycloadditions (SPAAC) by using cycloalkynes. DACNs possesses high thermal and chemical stability along with comparable click reactivity. DACN(Tos) hydrochloride can be used for the research of molecular conjugation .

HY-P4087B

Cys(Npys)-(Arg)9 acetate	HIV	Others
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-151752

Mal-AMCHC-N-Propargylamide	ADC Linker	Others
Mal-AMCHC-N-Propargylamide is a click chemistry reagent containing an azide group. Mal-AMCHC-N-Propargylamide can be a bio-conjugation reagent for antibody-agent-conjugate synthesis using Click-Chemistry .

HY-151640

Fmoc-DAP-N3	ADC Linker	Others
Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151766

DACN(Tos,Suc-OH)	ADC Linker	Others
DACN(Tos,Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity .

HY-151780

Fmoc-L-Dap(Pentynoyl)-OH	ADC Linker	Others
Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Dap(Pentynoyl)-OH serves as an amino acid building block for introducing alkyne functions into peptide sequences by standard Fmoc/tBu protocols. The alkyne residue can be engaged for copper catalyzed click reaction with organic azides or with tetrazines for copper-free conjugations . Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160473

TAM557	ADC Payload Microtubule/Tubulin	Cancer
TAM557 is a cytotoxic tubulysin compound that can be used in enzymatic conjugation reactions .

HY-P11541

CTP-Cys	Amino Acid Derivatives	Others
CTP-Cys is a cysteine attached to CTP (HY-P4094) for peptide conjugation .

HY-19318C

Fmoc-D-Val-D-Cit-PAB	ADC Linker	Cancer
Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC) .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N1423

Glycocholic acid 3 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor
Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) .

HY-128853

Taurodeoxycholate sodium 5+ Cited Publications	Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1 PARP Apoptosis NF-κB PKA
Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects .

HY-B1899

Taurodeoxycholic acid Maximum Cited Publications 7 Publications Verification Taurodeoxycholate	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1 PARP Apoptosis NF-κB PKA
Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects .

HY-122141

Glycohyocholic acid GHCA	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Glycohyocholic acid (GHCA) is a primary conjugated bile acid formed by the conjugation of Hyocholic acid (HY-121238) and Glycine (HY-Y0966). Glycohyocholic acid can be used as a biomarker in the study of hepatitis C-related cirrhosis and diabetes .

HY-W089835

Sodium taurodeoxycholate hydrate 1 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite PARP Apoptosis NF-κB PKA
Sodium taurodeoxycholate hydrate is a bile salt-related anionic detergent. Sodium taurodeoxycholate hydrate is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Sodium taurodeoxycholate hydrate is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d₆ (TDCA) exhibits anti-inflammatory and neuroprotective effects .

HY-N1423A

Glycocholic acid sodium 3 Publications Verification	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor Endogenous Metabolite
Glycocholic acid sodium is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid sodium inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid sodium modulates related bile acid receptor signaling. Glycocholic acid sodium suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid sodium can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) .

HY-113158

4-Hydroxyhippuric acid	Immune System Disorder Disease markers Endogenous metabolite	Drug Metabolite
4-Hydroxyhippuric acid is a metabolite of polyphenols. 4-Hydroxyhippuric acid is generated via medium-chain acyl-CoA dehydrogenase (MCAD)-dependent β-oxidation of microbially-produced 3-(4-hydroxyphenyl)propionic acid, followed by host glycine conjugation. 4-Hydroxyhippuric acid can be simultaneously detected in urine as a biomarker of dietary polyphenol intake .

HY-N1423B

Glycocholic acid hydrate 3 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Caspase G protein-coupled Bile Acid Receptor 1 LPL Receptor MDM-2/p53 Bcl-2 Family P-glycoprotein FXR Bacterial Apoptosis
Glycocholic acid hydrate is a bile acid derivative. Glycocholic acid hydrate downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid hydrate inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid hydrate modulates related bile acid receptor signaling. Glycocholic acid hydrate suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid hydrate can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) .

HY-B1899R

Taurodeoxycholic acid (Standard) Taurodeoxycholate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite G protein-coupled Bile Acid Receptor 1 PARP Apoptosis NF-κB PKA
Taurodeoxycholic acid (Standard) is the analytical standard of Taurodeoxycholic acid. This product is intended for research and analytical applications. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].

HY-128853R

Taurodeoxycholate sodium salt (Standard)	Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite G protein-coupled Bile Acid Receptor 1 PARP Apoptosis NF-κB PKA
Taurodeoxycholate sodium salt (Standard) is a bile salt (Standard)-related anionic detergent. Taurodeoxycholate sodium salt (Standard) is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt (Standard) is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects .

HY-122141R

Glycohyocholic acid (Standard) GHCA (Standard)	Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Glycohyocholic acid (Standard) is the analytical standard of Glycohyocholic acid (HY-122141). This product is intended for use in research and analytical applications. Glycohyocholic acid (GHCA) is a primary conjugated bile acid formed by the conjugation of Cholic acid (HY-N0324) and Glycine (HY-Y0966). Glycohyocholic acid can be used in the study of hepatitis C-related cirrhosis and diabetes mellitus .

HY-113158R

4-Hydroxyhippuric acid (Standard)	Immune System Disorder Disease markers Endogenous metabolite	Reference Standards Drug Metabolite
4-Hydroxyhippuric acid (Standard) is the analytical standard of 4-Hydroxyhippuric acid (HY-113158). This product is intended for research and analytical applications. 4-Hydroxyhippuric acid is a metabolite of polyphenols. 4-Hydroxyhippuric acid is generated via medium-chain acyl-CoA dehydrogenase (MCAD)-dependent β-oxidation of microbially-produced 3-(4-hydroxyphenyl)propionic acid, followed by host glycine conjugation. 4-Hydroxyhippuric acid can be simultaneously detected in urine as a biomarker of dietary polyphenol intake .

HY-N1423AR

Glycocholic acid sodium (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor Endogenous Metabolite
Glycocholic acid (sodium) (Standard) is the analytical standard of Glycocholic acid sodium (HY-N1423A). This product is intended for research and analytical applications. Glycocholic acid sodium is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid sodium inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid sodium modulates related bile acid receptor signaling. Glycocholic acid sodium suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid sodium can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

Cat. No.	상품명	Chemical Structure

HY-N1423S

Glycocholic acid-d4

Glycocholic acid-d₄ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-W016562S

Hippuric acid-d5
Hippuric acid-d₅ is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

HY-W016562S1

Hippuric acid-d2
Hippuric acid-d₂ is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

HY-113446S

Leukotriene C4-d5
Leukotriene C4-d₅ is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.

HY-128853S

Taurodeoxycholate-d6 sodium

Taurodeoxycholate-d₆ sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate-d₆ sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate-d₆ sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d₆ (TDCA) exhibits anti-inflammatory and neuroprotective effects .

HY-W016562S3

Hippuric acid-15N
Hippuric acid- ¹⁵N is the ¹⁵N-labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

HY-N1423S1

Glycocholic acid-d5

Glycocholic acid-d₅ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-118759S

DSP Crosslinker-d8
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker (HY-118759). DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W705390

Disuccinimidyl suberate Crosslinker-d4
Disuccinimidyl suberate Crosslinker-d₄ is the deuterium labeled Disuccinimidyl suberate Crosslinker (HY-W019543). Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697S

DSG Crosslinker-d4
DSG Crosslinker-d₄ (Disuccinimidyl glutarate-d₄) is the deuterium labeled DSG Crosslinker (HY-114697). DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-122141S

Glycohyocholic acid-d4
Glycohyocholic acid-d₄ is the deuterium labeled Glycohyocholic acid (HY-122141). Glycohyocholic acid (GHCA) is a primary conjugated bile acid formed by the conjugation of Cholic acid (HY-N0324) and Glycine (HY-Y0966). Glycohyocholic acid can be used in the study of hepatitis C-related cirrhosis and diabetes mellitus .

HY-W754548

Glycocholic acid-13C2,d4

Glycocholic acid- ¹³C₂,d₄ is the deuterium labeled and ¹³C-labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-124329AS

BS3 Crosslinker-d4 disodium
BS3 Crosslinker-d₄ disodium is the deuterium labeled BS3 Crosslinker. BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547S

BS2G Crosslinker-d4 disodium
BS2G Crosslinker-d₄ disodium is the deuterium labeled BS2G Crosslinker disodium (HY-130547). BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-128853S1

Taurodeoxycholat-d4 sodium

Taurodeoxycholat-d₄ sodium is the deuterium labeled Taurodeoxycholate sodium (HY-128853). Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects .

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-42360G

SMCC	ADC Linker	Inflammation/Immunology Cancer
SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

HY-128952G

Tesirine SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

HY-112005G

DOPE Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine	Ferroptosis Glutathione Peroxidase ACSL Family Amino acid Transporter	Neurological Disease Inflammation/Immunology
DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .

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