2. Metabolic Enzyme/Protease
  3. MMP
  4. GPLGIAGQC

GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles.

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GPLGIAGQC

GPLGIAGQC Chemical Structure

CAS No. : 1423719-70-3

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GPLGIAGQC Related Antibodies

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Description

GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles[1][2].

In Vitro

The GPLGIAGQC peptide (10-40 nM MMP2; 24 h) acts as an MMP2-cleavable linker in AP-PP-DOX nanoparticles, enabling sustained, MMP2-dependent release of DOX with minimal leakage in MMP2-deficient conditions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPLGIAGQC Related Antibodies
Molecular Weight

814.95

Formula

C34H58N10O11S
CAS No.
Sequence

Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln-Cys
Sequence Shortening

GPLGIAGQC
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPLGIAGQC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPLGIAGQC1423719-70-3MMPMatrix metalloproteinasesMMP2-cleavable peptideglycineisoleucineInhibitorinhibitorinhibit

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