Bis-PEG3-NHS ester
Based on 1 Customer Validation
Bis-PEG3-NHS ester is a nonclaevable 3-unit PEG linker for antibody-agent-conjugation (ADC).
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 1314378-16-9
- Formula: C18H24N2O11
- Molecular Weight:444.39
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Non-cleavable Linker |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1314378-16-9
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Appearance Solid
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Molecular Weight 444.39
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Formula C18H24N2O11
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Color White to off-white
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (225.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (241 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2503 mL | 11.2514 mL | 22.5028 mL | 56.2569 mL |
| 5 mM | 0.4501 mL | 2.2503 mL | 4.5006 mL | 11.2514 mL | |
| 10 mM | 0.2250 mL | 1.1251 mL | 2.2503 mL | 5.6257 mL | |
| 15 mM | 0.1500 mL | 0.7501 mL | 1.5002 mL | 3.7505 mL | |
| 20 mM | 0.1125 mL | 0.5626 mL | 1.1251 mL | 2.8128 mL | |
| 25 mM | 0.0900 mL | 0.4501 mL | 0.9001 mL | 2.2503 mL | |
| 30 mM | 0.0750 mL | 0.3750 mL | 0.7501 mL | 1.8752 mL | |
| 40 mM | 0.0563 mL | 0.2813 mL | 0.5626 mL | 1.4064 mL | |
| 50 mM | 0.0450 mL | 0.2250 mL | 0.4501 mL | 1.1251 mL | |
| 60 mM | 0.0375 mL | 0.1875 mL | 0.3750 mL | 0.9376 mL | |
| 80 mM | 0.0281 mL | 0.1406 mL | 0.2813 mL | 0.7032 mL | |
| 100 mM | 0.0225 mL | 0.1125 mL | 0.2250 mL | 0.5626 mL |
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