Low molecular weight protamine acetate

Low molecular weight protamine (18 μg/U; 3 min) acetate completely neutralizes the aPTT activity of 5 U/mL heparin in human plasma at a ratio of 18 μg/U, requiring a dose ~2.4-fold higher than protamine^[1].
Low molecular weight protamine (12 μg/U; 10 min) acetate completely neutralizes the anti-IIa activity of 1 U/mL heparin in human plasma at a ratio of 12 μg/U, requiring a dose ~1.6-fold higher than protamine^[1].
Low molecular weight protamine (30 μg/μg) acetate completely neutralizes the anti-Xa activity of Mono-Embolex at a ratio of 30 μg/μg, with efficacy similar to protamine^[1].
Low molecular weight protamine (100 μg/U) acetate completely neutralizes the anti-Xa activity of both Fragmin and LMWH3000 at a ratio of 100 μg/U, demonstrating broad efficacy against low molecular weight heparins^[1].
Low molecular weight protamine (4.5 mg/mL; 60 min at 37°C) acetate induces only 30% complement consumption in diluted human serum, showing drastically reduced complement activation potential compared to protamine^[1].
Heparin-Low molecular weight protamine acetate complexes (22 μg/U; 60 min at 37°C), formed at a ratio of 22 μg/U, induce only ~50% complement consumption in human serum with 2.5-10 U/mL heparin, showing reduced complement activation potential compared to heparin-protamine complexes^[1].
Low molecular weight protamine (63 μM; 2 h at 37°C) acetate acetate cross-reacts with mouse antiprotamine antibodies with a IC₅₀ of 63 μM, showing ~5.25-fold lower cross-reactivity than protamine^[1].
The Low molecular weight protamine acetate-gelonin conjugate potently inhibits protein synthesis in a cell-free rabbit reticulocyte lysate system with an IC₅₀ of ~23 pM^[2].
FITC-labeled Low molecular weight protamine (TDSP5) (0.2 μM; 30 min) acetate is efficiently taken up by 293T, HeLa, CT-26, MCF-7, NIH3T3, and MG63 cells, with uptake efficiency equivalent to TAT peptide and protamine and unaffected by 10% serum^[2].
Low molecular weight protamine (TDSP5) acetate (0.2 μM; 30 min) efficiently translocates into HeLa, CT-26, and MG63 cells, localizes to the cytoplasm, and effectively delivers conjugated phalloidin and gelonin into cells^[2].
Low molecular weight protamine (TDSP5) (0.01-10.0 mM; 72 h) acetate exhibits minimal cytotoxicity toward 293T cells, with less than 10% reduction in cell viability at concentrations up to 10.0 mM after 72 h incubation^[2].
The Low molecular weight protamine acetate -gelonin conjugate (1:1 molar ratio) (48 h) potently inhibits CT-26 colon adenocarcinoma cell growth with an IC₅₀ of 39 pM after 48 h incubation, while free gelonin or free LMWP plus gelonin have no effect^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.