Fmoc-D-Val-D-Cit-PAB

Cat. No.: HY-19318C Purity: 98.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC).

For research use only. We do not sell to patients.

Fmoc-D-Val-D-Cit-PAB Chemical Structure

CAS No. : 1350456-69-7

Size	Price	Stock	Quantity
50 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Fmoc-D-Val-D-Cit-PAB:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Molecular Weight

601.69

Formula

C₃₃H₃₉N₅O₆

CAS No.

1350456-69-7

Appearance

Solid

Color

White to off-white

SMILES

OCC(C=C1)=CC=C1NC([C@@H](CCCNC(N)=O)NC([C@@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (166.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6620 mL	8.3099 mL	16.6199 mL
5 mM	0.3324 mL	1.6620 mL	3.3240 mL
10 mM	0.1662 mL	0.8310 mL	1.6620 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.97%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (311 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Peter D. Senter, et al. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease.WO2004010957A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6620 mL	8.3099 mL	16.6199 mL	41.5496 mL
	5 mM	0.3324 mL	1.6620 mL	3.3240 mL	8.3099 mL
	10 mM	0.1662 mL	0.8310 mL	1.6620 mL	4.1550 mL
	15 mM	0.1108 mL	0.5540 mL	1.1080 mL	2.7700 mL
	20 mM	0.0831 mL	0.4155 mL	0.8310 mL	2.0775 mL
	25 mM	0.0665 mL	0.3324 mL	0.6648 mL	1.6620 mL
	30 mM	0.0554 mL	0.2770 mL	0.5540 mL	1.3850 mL
	40 mM	0.0415 mL	0.2077 mL	0.4155 mL	1.0387 mL
	50 mM	0.0332 mL	0.1662 mL	0.3324 mL	0.8310 mL
	60 mM	0.0277 mL	0.1385 mL	0.2770 mL	0.6925 mL
	80 mM	0.0208 mL	0.1039 mL	0.2077 mL	0.5194 mL
	100 mM	0.0166 mL	0.0831 mL	0.1662 mL	0.4155 mL