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  2. Angiopep-2 hydrochloride

Angiopep-2 hydrochloride 

Cat. No.: HY-P2341
Handling Instructions

Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiopep-2 hydrochloride Chemical Structure

Angiopep-2 hydrochloride Chemical Structure

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Description

Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer[1].

In Vitro

Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel– Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar to that of paclitaxel against human cancer cell lines[1].

In Vivo

ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells[1].

Molecular Weight

2337.93

Formula

C₁₀₄H₁₅₀ClN₂₉O₃₁

Sequence

{Thr}{Phe}{Phe}{Tyr}{Gly}{Gly}{Ser}{Arg}{Gly}{Lys}{Arg}{Asn}{Asn}{Phe}{Lys}{Thr}{Glu}{Glu}{Tyr}

Sequence Shortening

TFFYGGSRGKRNNFKTEEY

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Angiopep-2Angiopep2Angiopep 2OthersInhibitorinhibitorinhibit

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Angiopep-2 hydrochloride
Cat. No.:
HY-P2341
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