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  2. Angiopep-2 hydrochloride

Angiopep-2 hydrochloride 

Cat. No.: HY-P2341 Purity: 97.44%
Handling Instructions

Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiopep-2 hydrochloride Chemical Structure

Angiopep-2 hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 140 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer[1].

In Vitro

Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel– Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar to that of paclitaxel against human cancer cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2337.93

Formula

C₁₀₄H₁₅₀ClN₂₉O₃₁

Sequence

Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr

Sequence Shortening

TFFYGGSRGKRNNFKTEEY

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (42.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4277 mL 2.1386 mL 4.2773 mL
5 mM 0.0855 mL 0.4277 mL 0.8555 mL
10 mM 0.0428 mL 0.2139 mL 0.4277 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Angiopep-2Angiopep2Angiopep 2OthersInhibitorinhibitorinhibit

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Product Name:
Angiopep-2 hydrochloride
Cat. No.:
HY-P2341
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