(R)-I-BET762 carboxylic acid
Based on 1 Customer Validation
(R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1.
For research use only. We do not sell to patients.
- Purity : 99.50%
- CAS No.: 1786401-70-4
- Formula: C20H17ClN4O3
- Molecular Weight:396.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 1786401-70-4
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Appearance Solid
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Molecular Weight 396.83
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Formula C20H17ClN4O3
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Color Off-white to light yellow
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SMILES
CC1=NN=C2[C@@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21
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Synonyms
(R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (252.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5200 mL | 12.5999 mL | 25.1997 mL | 62.9993 mL |
| 5 mM | 0.5040 mL | 2.5200 mL | 5.0399 mL | 12.5999 mL | |
| 10 mM | 0.2520 mL | 1.2600 mL | 2.5200 mL | 6.2999 mL | |
| 15 mM | 0.1680 mL | 0.8400 mL | 1.6800 mL | 4.2000 mL | |
| 20 mM | 0.1260 mL | 0.6300 mL | 1.2600 mL | 3.1500 mL | |
| 25 mM | 0.1008 mL | 0.5040 mL | 1.0080 mL | 2.5200 mL | |
| 30 mM | 0.0840 mL | 0.4200 mL | 0.8400 mL | 2.1000 mL | |
| 40 mM | 0.0630 mL | 0.3150 mL | 0.6300 mL | 1.5750 mL | |
| 50 mM | 0.0504 mL | 0.2520 mL | 0.5040 mL | 1.2600 mL | |
| 60 mM | 0.0420 mL | 0.2100 mL | 0.4200 mL | 1.0500 mL | |
| 80 mM | 0.0315 mL | 0.1575 mL | 0.3150 mL | 0.7875 mL | |
| 100 mM | 0.0252 mL | 0.1260 mL | 0.2520 mL | 0.6300 mL |
(R)-I-BET762 carboxylic acid Related Classifications
HY-107443A Related Classifications
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