1. PROTAC
    Epigenetics
  2. Ligand for Target Protein for PROTAC
    Epigenetic Reader Domain
  3. I-BET762 carboxylic acid

I-BET762 carboxylic acid (Synonyms: Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2)

Cat. No.: HY-107443 Purity: 96.04% ee.: 99.52%
Handling Instructions

I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.

For research use only. We do not sell to patients.

I-BET762 carboxylic acid Chemical Structure

I-BET762 carboxylic acid Chemical Structure

CAS No. : 1300019-38-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 288 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of I-BET762 carboxylic acid:

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Description

I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1[1].

IC50 & Target[1]

BRD4

5.1 (pIC50)

In Vitro

I-BET762 carboxylic acid (Molibresib carboxylic acid) (Compound 27) inhibits peripheral blood mononuclear cells (PBMC) with a pIC50 of <4[1].

Molecular Weight

396.83

Formula

C₂₀H₁₇ClN₄O₃

CAS No.

1300019-38-8

SMILES

CC1=NN=C2[[email protected]](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.14 mg/mL (17.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5200 mL 12.5999 mL 25.1997 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL
10 mM 0.2520 mL 1.2600 mL 2.5200 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

I-BET762 carboxylic acidMolibresib carboxylic acidGSK525762A carboxylic acidPROTAC BRD4-binding moiety 2Ligand for Target Protein for PROTACEpigenetic Reader DomainTarget Protein-binding MoietyInhibitorinhibitorinhibit

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Product name:
I-BET762 carboxylic acid
Cat. No.:
HY-107443
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