VCP-Eribulin

Cat. No.: HY-128871: FAQs
Data Sheet Handling Instructions

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VCP-Eribulin consists the ADCs linker (VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. VCP-Eribulin is an Eribulin-based agent for antibody conjugates.

For research use only. We do not sell to patients.

VCP-Eribulin Chemical Structure

CAS No. : 2130869-17-7

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Biological Activity
Purity & Documentation
References
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Description

VCP-Eribulin consists the ADCs linker (VCP) and Eribulin^[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer^[2]. VCP-Eribulin is an Eribulin-based agent for antibody conjugates^[1].

IC₅₀ & Target

Traditional Cytotoxic Agents

Molecular Weight

1135.34

Formula

C₅₉H₈₆N₆O₁₆

CAS No.

2130869-17-7

SMILES

C=C1C[C@@]2([H])O[C@@]1([H])CC[C@]3([H])O[C@](C([C@H](C)C3)=C)([H])C[C@@]4([H])[C@]([C@@H](OC)[C@@H](C[C@H](O)CNC(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O)=O)C=C5)=O)O4)([H])CC(C[C@]6([H])O[C@]7([H])[C@]8([H])O[C@@]9(O[C@@]%10([H])[C@@](O[C@]8([H])[C@@]%10([H])O[C@@]7([H])CC6)([H])C9)CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

[2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505. [Content Brief]

VCP-Eribulin Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VCP-Eribulin2130869-17-7Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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