DOTA-Pep-1L
DOTA-Pep-1L is a polypeptide formed by the conjugation of DOTA and Pep-1L. DOTA-Pep-1L specifically binds to IL13RA2 and can be used for the synthesis of targeted polypeptides. DOTA-Pep-1L yields the isotopically labeled product [225Ac]DOTA-Pep-1L, which exerts α-radiation killing effects on orthotopic glioma cells and extends the median survival time of mice bearing orthotopic glioma models after stereotactic injection. DOTA-Pep-1L can be used for PET imaging, tumor targeting and glioma research.
For research use only. We do not sell to patients.
- Formula: C88H146N28O27S3
- Molecular Weight:2124.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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IL-13 |
DOTA-Pep-1L labeled with [225Ac] (1 µCi (0.04 MBq); intracranial infusion via convection-enhanced delivery; single dose) is well-tolerated and provides significant anti-glioblastoma efficacy, as evidenced by a median survival of 41 days, reduced tumor volume, and induction of tumor cell death and reduced proliferation in orthotopic U251 glioblastoma-bearing mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 2124.47
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Formula C88H146N28O27S3
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Sequence
Ala-Cys-Gly-Glu-Met-Gly-Trp-Val-Arg-Cys-Gly-Gly-Gly-Ser-{Ahx}-Lys-Lys(DOTA)-NH2
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Sequence Shortening
ACGEMGWVRCGGGS-{Ahx}-K-Lys(DOTA)-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Phipps MD, et al. Current State of Targeted Radiometal-Based Constructs for the Detection and Treatment of Disease in the Brain. Bioconjug Chem. 2021;32(7):1331-1347. [Content Brief]
[2]. Sattiraju A, et al. IL13RA2 targeted alpha particle therapy against glioblastomas. Oncotarget. 2017;8(26):42997-43007. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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