1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Propargyl-PEG1-NHS ester

Propargyl-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC). Propargyl-PEG1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG1-NHS ester Chemical Structure

Propargyl-PEG1-NHS ester Chemical Structure

CAS No. : 1174157-65-3

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25 mg USD 50 In-stock
50 mg USD 80 In-stock
100 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Propargyl-PEG1-NHS ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC). Propargyl-PEG1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Non-cleavable Linker

 

Molecular Weight

225.20

Formula

C10H11NO5

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (444.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4405 mL 22.2025 mL 44.4050 mL
5 mM 0.8881 mL 4.4405 mL 8.8810 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4405 mL 22.2025 mL 44.4050 mL 111.0124 mL
5 mM 0.8881 mL 4.4405 mL 8.8810 mL 22.2025 mL
10 mM 0.4440 mL 2.2202 mL 4.4405 mL 11.1012 mL
15 mM 0.2960 mL 1.4802 mL 2.9603 mL 7.4008 mL
20 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
25 mM 0.1776 mL 0.8881 mL 1.7762 mL 4.4405 mL
30 mM 0.1480 mL 0.7401 mL 1.4802 mL 3.7004 mL
40 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
50 mM 0.0888 mL 0.4440 mL 0.8881 mL 2.2202 mL
60 mM 0.0740 mL 0.3700 mL 0.7401 mL 1.8502 mL
80 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL
100 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1101 mL
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Propargyl-PEG1-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Propargyl-PEG1-NHS ester
Cat. No.:
HY-126513
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