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Cat. No.: HY-P11339

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c-RGD-SH

c-RGD-SH is a ligand for integrin αvβ3 (Integrin αvβ3). Conjugation of c-RGD-SH with core-crosslinked polymeric micelles (CCPM) enables the synthesis of a bimodal nanoprobe, which can be labeled with Cy7 and 111In for SPECT and NIRF imaging of tumors.

For research use only. We do not sell to patients.

CAS No.: 841255-57-0
Formula: C₂₉H₄₃N₉O₈S
Molecular Weight:677.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

c-RGD-SH Chemical Structure

CAS No.: 841255-57-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

αvβ3

All Integrin Isoforms :

In Vivo

c-RGD-SH-conjugated P1RGD NPs (i.v.) deliver enhanced tumor-targeted PA imaging performance in subcutaneous glioblastoma xenografts, achieving a 95 signal-to-background ratio 24 hours post-injection^[1].
c-RGD-SH-conjugated P1RGD NPs (i.v.) enable effective PA imaging of deep orthotopic glioblastoma tumors, with superior signal-to-background performance compared to non-targeted controls^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 841255-57-0
Molecular Weight 677.77
Formula C₂₉H₄₃N₉O₈S
Sequence

c(Arg-Gly-Asp-dPhe-Lys)-SH
Sequence Shortening

c(RGD-dPhe-K)-SH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao Z, et al. Targeted contrast agents and activatable probes for photoacoustic imaging of cancer. Chem Soc Rev. 2022;51(3):829-868. Published 2022 Feb 7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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c-RGD-SH

All Integrin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

c-RGD-SH Related Classifications

HY-P11339 Related Classifications