2. Inhibitory Antibodies
  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. REGN3124

REGN3124 is a fully human antibody with binding to EGFRvIII. REGN3124 forms REGN3124-PBD via conjugation to pyrrolobenzodiazepine linker-payload SG-3249. REGN3124 can be used for the research of glioblastoma multiforme.

For research use only. We do not sell to patients.

REGN3124

REGN3124 Chemical Structure

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REGN3124 Related Antibodies

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Description

REGN3124 is a fully human antibody with binding to EGFRvIII. REGN3124 forms REGN3124-PBD via conjugation to pyrrolobenzodiazepine linker-payload SG-3249. REGN3124 can be used for the research of glioblastoma multiforme[1].

Species Reactivity

Human
Parmacokinetics
Species Dose Route Cmax Tmax AUClast MRTlast CL Vd T1/2
Rhesus monkey[1] 6 mg/kg i.v. 148.38 μg/mL 1.00 h 6900.24 mg·h/L 62.23 h 0.86 mL/h/kg 62.56 mL/kg 51.60 h
Rhesus monkey[1] 18 mg/kg i.v. 352.71 μg/mL 1.00 h 25398.82 mg·h/L 103.93 h 0.72 mL/h/kg 106.51 mL/kg 104.62 h
Rhesus monkey[1] 54 mg/kg i.v. 985.25 μg/mL 1.00 h 72301.13 mg·h/L 127.46 h 0.79 mL/h/kg 139.83 mL/kg 130.72 h
Gene ID

1956  [NCBI]

Accession
Target

ERBB1/EGFR/HER1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[REGN3124]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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REGN3124 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

REGN3124REGN 3124REGN-3124cell line xenograft mouse modelspyrrolobenzodiazepine linker-payload SG-3249patient-derived xenograftglioblastoma multiformeEGFRvIIIwild-type EGFRInhibitorinhibitorinhibit

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HY-P991970
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