REGN3124
REGN3124 is a fully human antibody with binding to EGFRvIII. REGN3124 forms REGN3124-PBD via conjugation to pyrrolobenzodiazepine linker-payload SG-3249. REGN3124 can be used for the research of glioblastoma multiforme.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Human
| Species | Dose | Route | Cmax | Tmax | AUClast | MRTlast | CL | Vd | T1/2 |
|---|---|---|---|---|---|---|---|---|---|
| Rhesus monkey[1] | 6 mg/kg | i.v. | 148.38 μg/mL | 1.00 h | 6900.24 mg·h/L | 62.23 h | 0.86 mL/h/kg | 62.56 mL/kg | 51.60 h |
| Rhesus monkey[1] | 18 mg/kg | i.v. | 352.71 μg/mL | 1.00 h | 25398.82 mg·h/L | 103.93 h | 0.72 mL/h/kg | 106.51 mL/kg | 104.62 h |
| Rhesus monkey[1] | 54 mg/kg | i.v. | 985.25 μg/mL | 1.00 h | 72301.13 mg·h/L | 127.46 h | 0.79 mL/h/kg | 139.83 mL/kg | 130.72 h |
ERBB1/EGFR/HER1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[REGN3124]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
REGN3124 Related Classifications
HY-P991970 Related Classifications
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