SV119 hydrochloride

Cat. No.: HY-177345A: Data Sheet Handling Instructions
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SV119 hydrochloride is a sigma-2 ligand with a K_i value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis.

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SV119 hydrochloride Chemical Structure

CAS No. : 913816-12-3

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Other Forms of SV119 hydrochloride:

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Description	SV119 hydrochloride is a sigma-2 ligand with a K_i value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis^[1]^[2].
Molecular Weight	476.48
Formula	C₂₃H₃₉Cl₂N₃O₃
CAS No.	913816-12-3
SMILES	NCCCCCCN([C@@]1([H])C2)[C@](CCC1)([H])C[C@H]2OC(NC(C=C3C)=C(C=C3)OC)=O.Cl.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Takchi R, et al. Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress. Cell Death Dis. 2024 May 2;15(5):309. [Content Brief] [2]. Zongyi Liu, et al. Abstract 5428: Sigma-2 receptor-induced cell death: a novel approach to triple-negative breast cancer treatment. Cancer Res (2015) 75 (15_Supplement): 5428.