913816-12-3
Chemical Structure
SV119 hydrochloride
- CAS. Nr.: 913816-12-3
- Formula:C23H39Cl2N3O3
- Molecular Weight:476.48
InChIKey: HIZZPDIGGSORTQ-PCKABBHRSA-N
SMILES: NCCCCCCN([C@@]1([H])C2)[C@](CCC1)([H])C[C@H]2OC(NC(C=C3C)=C(C=C3)OC)=O.Cl.Cl
Biological Activity: SV119 hydrochloride is a sigma-2 ligand with a Ki value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis[1][2].
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SV119 hydrochloride | SV119 hydrochloride is a sigma-2 ligand with a Ki value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis. | |||||||||||||||||||||
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- [1]. Takchi R, et al. Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress. Cell Death Dis. 2024 May 2;15(5):309. [Content Brief]
- [2]. Zongyi Liu, et al. Abstract 5428: Sigma-2 receptor-induced cell death: a novel approach to triple-negative breast cancer treatment. Cancer Res (2015) 75 (15_Supplement): 5428.
Keywords
