N-Fmoc-8-aminooctanoic acid
Based on 1 Customer Validation
N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
For research use only. We do not sell to patients.
- Purity: 98.95%
- CAS No.: 126631-93-4
- Formula: C23H27NO4
- Molecular Weight:381.46
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 126631-93-4
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Appearance Solid
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Molecular Weight 381.46
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Formula C23H27NO4
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Color White to off-white
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SMILES
OC(CCCCCCCNC(OCC1C2=CC=CC=C2C3=C1C=CC=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (262.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (241 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6215 mL | 13.1075 mL | 26.2151 mL | 65.5377 mL |
| 5 mM | 0.5243 mL | 2.6215 mL | 5.2430 mL | 13.1075 mL | |
| 10 mM | 0.2622 mL | 1.3108 mL | 2.6215 mL | 6.5538 mL | |
| 15 mM | 0.1748 mL | 0.8738 mL | 1.7477 mL | 4.3692 mL | |
| 20 mM | 0.1311 mL | 0.6554 mL | 1.3108 mL | 3.2769 mL | |
| 25 mM | 0.1049 mL | 0.5243 mL | 1.0486 mL | 2.6215 mL | |
| 30 mM | 0.0874 mL | 0.4369 mL | 0.8738 mL | 2.1846 mL | |
| 40 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6384 mL | |
| 50 mM | 0.0524 mL | 0.2622 mL | 0.5243 mL | 1.3108 mL | |
| 60 mM | 0.0437 mL | 0.2185 mL | 0.4369 mL | 1.0923 mL | |
| 80 mM | 0.0328 mL | 0.1638 mL | 0.3277 mL | 0.8192 mL | |
| 100 mM | 0.0262 mL | 0.1311 mL | 0.2622 mL | 0.6554 mL |
N-Fmoc-8-aminooctanoic acid Related Classifications
HY-W009030 Related Classifications
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