Bis-PEG2-NHS ester

Name: Bis-PEG2-NHS ester
Brand: MedChemExpress
SKU: HY-130088
Rating: 4.5 (1 reviews)

Cat. No.: HY-130088 Purity: 99.24%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Bis-PEG2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).

For research use only. We do not sell to patients.

Bis-PEG2-NHS ester Chemical Structure

CAS No. : 65869-63-8

Size	Stock	Quantity
Free Sample (0.1 - 0.2 mg)	Apply Now
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
Customer Review

Description

Bis-PEG2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).

IC₅₀ & Target

Non-cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

400.34

Formula

C₁₆H₂₀N₂O₁₀

CAS No.

65869-63-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCC(ON2C(CCC2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (249.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4979 mL	12.4894 mL	24.9788 mL
5 mM	0.4996 mL	2.4979 mL	4.9958 mL
10 mM	0.2498 mL	1.2489 mL	2.4979 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.24%

Select Batch:

Data Sheet (242 KB) SDS (393 KB)

COA (247 KB) HNMR (112 KB) RP-HPLC (224 KB) MS (302 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4979 mL	12.4894 mL	24.9788 mL	62.4469 mL
	5 mM	0.4996 mL	2.4979 mL	4.9958 mL	12.4894 mL
	10 mM	0.2498 mL	1.2489 mL	2.4979 mL	6.2447 mL
	15 mM	0.1665 mL	0.8326 mL	1.6653 mL	4.1631 mL
	20 mM	0.1249 mL	0.6245 mL	1.2489 mL	3.1223 mL
	25 mM	0.0999 mL	0.4996 mL	0.9992 mL	2.4979 mL
	30 mM	0.0833 mL	0.4163 mL	0.8326 mL	2.0816 mL
	40 mM	0.0624 mL	0.3122 mL	0.6245 mL	1.5612 mL
	50 mM	0.0500 mL	0.2498 mL	0.4996 mL	1.2489 mL
	60 mM	0.0416 mL	0.2082 mL	0.4163 mL	1.0408 mL
	80 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7806 mL
	100 mM	0.0250 mL	0.1249 mL	0.2498 mL	0.6245 mL