MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)

Name: MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
Brand: MedChemExpress
SKU: HY-156515
Rating: 4.5 (0 reviews)

製品番号: HY-156515 純度: 95.61%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) is a drug-linker conjugate for ADC, formed by conjugation of 7ethanol-10NH2-11F-Camptothecin (HY-156517) with the protease-cleavable MC-GGFG linker. MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) is applicable for cancer research.

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MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) 構造式

CAS 番号 : 2987937-38-0

容量	価格（税別）	在庫状況	数量
1 mg	$550	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Camptothecins

体外実験

MC-GGFG-(7ethanol-10NH₂-11F-Camptothecin) consists of 7ethanol-10NH₂-11F-Camptothecin (HY-156517) linked to the protease-degradable MC-GGFG moiety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

922.91

分子式

C₄₆H₄₇FN₈O₁₂

CAS 番号

2987937-38-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(F)=C(NC(CNC([C@@H](NC(CNC(CNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)C=C51

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 110 mg/mL (119.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0835 mL	5.4176 mL	10.8353 mL
5 mM	0.2167 mL	1.0835 mL	2.1671 mL
10 mM	0.1084 mL	0.5418 mL	1.0835 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.75 mg/mL (2.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 95.61%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (248 KB) HNMR (203 KB) RP-HPLC (259 KB) LCMS (99 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jeffrey A. Toretsky, et al. Camptothecin analogues, conjugates and methods of use. WO2022246576A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0835 mL	5.4176 mL	10.8353 mL	27.0882 mL
	5 mM	0.2167 mL	1.0835 mL	2.1671 mL	5.4176 mL
	10 mM	0.1084 mL	0.5418 mL	1.0835 mL	2.7088 mL
	15 mM	0.0722 mL	0.3612 mL	0.7224 mL	1.8059 mL
	20 mM	0.0542 mL	0.2709 mL	0.5418 mL	1.3544 mL
	25 mM	0.0433 mL	0.2167 mL	0.4334 mL	1.0835 mL
	30 mM	0.0361 mL	0.1806 mL	0.3612 mL	0.9029 mL
	40 mM	0.0271 mL	0.1354 mL	0.2709 mL	0.6772 mL
	50 mM	0.0217 mL	0.1084 mL	0.2167 mL	0.5418 mL
	60 mM	0.0181 mL	0.0903 mL	0.1806 mL	0.4515 mL
	80 mM	0.0135 mL	0.0677 mL	0.1354 mL	0.3386 mL
	100 mM	0.0108 mL	0.0542 mL	0.1084 mL	0.2709 mL