MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)

Name: MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
Brand: MedChemExpress
SKU: HY-156515
Rating: 4.5 (1 reviews)

Cat. No.: HY-156515 Purity: 95.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) is a drug-linker conjugates for ADC. MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) is a MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) with protease cleavable MC-GGFG linker.

For research use only. We do not sell to patients.

MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) Chemical Structure

CAS No. : 2987937-38-0

Size	Price	Stock	Quantity
1 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Camptothecins

Molecular Weight

922.91

Formula

C₄₆H₄₇FN₈O₁₂

CAS No.

2987937-38-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(F)=C(NC(CNC([C@@H](NC(CNC(CNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)C=C51

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 110 mg/mL (119.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0835 mL	5.4176 mL	10.8353 mL
5 mM	0.2167 mL	1.0835 mL	2.1671 mL
10 mM	0.1084 mL	0.5418 mL	1.0835 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.75 mg/mL (2.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 95.61%

Select Batch:

Data Sheet (270 KB) SDS (0 KB)

COA (248 KB) HNMR (203 KB) RP-HPLC (259 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Jeffrey A. Toretsky, et al. Camptothecin analogues, conjugates and methods of use. WO2022246576A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0835 mL	5.4176 mL	10.8353 mL	27.0882 mL
	5 mM	0.2167 mL	1.0835 mL	2.1671 mL	5.4176 mL
	10 mM	0.1084 mL	0.5418 mL	1.0835 mL	2.7088 mL
	15 mM	0.0722 mL	0.3612 mL	0.7224 mL	1.8059 mL
	20 mM	0.0542 mL	0.2709 mL	0.5418 mL	1.3544 mL
	25 mM	0.0433 mL	0.2167 mL	0.4334 mL	1.0835 mL
	30 mM	0.0361 mL	0.1806 mL	0.3612 mL	0.9029 mL
	40 mM	0.0271 mL	0.1354 mL	0.2709 mL	0.6772 mL
	50 mM	0.0217 mL	0.1084 mL	0.2167 mL	0.5418 mL
	60 mM	0.0181 mL	0.0903 mL	0.1806 mL	0.4515 mL
	80 mM	0.0135 mL	0.0677 mL	0.1354 mL	0.3386 mL
	100 mM	0.0108 mL	0.0542 mL	0.1084 mL	0.2709 mL