1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Ald-Ph-NHS ester

Ald-Ph-NHS ester 

Cat. No.: HY-130107 Purity: >97.0%
Handling Instructions

Ald-Ph-NHS ester is a nonclaevable linker for antibody-drug-conjugation (ADC).

For research use only. We do not sell to patients.

Ald-Ph-NHS ester Chemical Structure

Ald-Ph-NHS ester Chemical Structure

CAS No. : 60444-78-2

Size Price Stock Quantity
50 mg USD 130 In-stock
Estimated Time of Arrival: December 31
100 mg USD 195 In-stock
Estimated Time of Arrival: December 31
250 mg USD 350 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Description

Ald-Ph-NHS ester is a nonclaevable linker for antibody-drug-conjugation (ADC).

IC50 & Target

Non-cleavable

 

Molecular Weight

247.20

Formula

C₁₂H₉NO₅

CAS No.

60444-78-2

SMILES

O=C(ON1C(CCC1=O)=O)C2=CC=C(C=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (404.53 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0453 mL 20.2265 mL 40.4531 mL
5 mM 0.8091 mL 4.0453 mL 8.0906 mL
10 mM 0.4045 mL 2.0227 mL 4.0453 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (10.11 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Ald-Ph-NHS esterADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
Ald-Ph-NHS ester
Cat. No.:
HY-130107
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