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SR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Scavenger Receptor Class B type I (SR-BI） (7) 5 alpha Reductase (2) 5-HT Receptor (8) Adrenergic Receptor (10) Akt (6) AMPK (1) Anaplastic lymphoma kinase (ALK) (4) Angiotensin Receptor (8) Antibiotic (2) AP-1 (2) Apolipoprotein (1) Apoptosis (22) Aryl Hydrocarbon Receptor (4) ATGL (1) Aurora Kinase (1) Autophagy (11) Bacterial (9) Bcl-2 Family (2) Biochemical Assay Reagents (9) c-Kit (1) Calcium Channel (15) Cannabinoid Receptor (8) Casein Kinase (5) Caspase (2) CD38 (1) CDK (6) Cholecystokinin Receptor (3) COX (3) CXCR (1) Cyclophilin (1) Cytochrome P450 (4) Discoidin Domain Receptor (1) DNA/RNA Synthesis (2) Dopamine Receptor (3) Drug Derivative (5) Drug Isomer (1) Drug Metabolite (5) Drug-Linker Conjugates for ADC (1) EGFR (2) Endogenous Metabolite (2) Epigenetic Reader Domain (3) ERK (3) Estrogen Receptor/ERR (3) Factor Xa (2) FAK (2) FLT3 (1) Fluorescent Dye (4) Free Fatty Acid Receptor (1) Fungal (1) GABA Receptor (6) Glutathione Peroxidase (1) GPR35 (1) HCV (2) HDAC (1) HMG-CoA Reductase (HMGCR) (3) iGluR (1) IKK (2) Integrin (2) Interleukin Related (1) Isotope-Labeled Compounds (13) JAK (1) JNK (6) Kinesin (1) KLF (2) Leukotriene Receptor (3) LIM Kinase (LIMK) (1) LPL Receptor (1) LXR (5) mAChR (4) MAGL (1) MASTL (1) MetAP (1) Molecular Glues (1) Monoamine Oxidase (1) nAChR (1) NADPH Oxidase (1) Neurokinin Receptor (7) Neuropeptide Y Receptor (1) Neurotensin Receptor (7) NF-κB (2) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (1) Opioid Receptor (6) Orphan Nuclear Receptor (1) p38 MAPK (6) Parasite (5) PGC-1α (3) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (4) PKC (5) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (3) PPAR (10) Pregnane X Receptor (PXR) (2) PROTACs (5) RAR/RXR (3) Ras (2) Reactive Oxygen Species (ROS) (1) Reference Standards (28) Renin (2) REV-ERB (11) ROCK (2) ROR (10) SARS-CoV (2) Ser/Thr Protease (1) Serotonin Transporter (1) Sigma Receptor (2) Sirtuin (1) Small Interfering RNA (siRNA) (3) Sodium Channel (4) SRPK (1) Steroid Sulfatase (1) STING (4) TGF-beta/Smad (1) Thrombin (3) Thyroid Hormone Receptor (3) TNF Receptor (1) Topoisomerase (1) Trk Receptor (3) Tyrosine Hydroxylase (3) ULK (1) Vasopressin Receptor (2) Virus Protease (2) Wnt (1)
By Research Areas:	Cancer (90) Cardiovascular Disease (45) Endocrinology (11) Infection (17) Inflammation/Immunology (43) Metabolic Disease (50) Neurological Disease (59)
Click Chemistry:	DBCO (1) Alkynes (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

271

Inhibitors & Agonists

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GMP Molecules

Targets Recommended: Serine Racemase (SR) CaSR Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15870

SR 11302 20+ Cited Publications	AP-1	Inflammation/Immunology Cancer
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-131454

SR-717 25+ Cited Publications	STING	Inflammation/Immunology Cancer
SR-717 is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

HY-14415

SR8278 10+ Cited Publications	REV-ERB	Neurological Disease Metabolic Disease
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC₅₀ of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease .

HY-14136

Rimonabant 10+ Cited Publications SR141716	Cannabinoid Receptor Bacterial	Infection Metabolic Disease Cancer
Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a K_i of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-18345

SR 49059 3 Publications Verification	Vasopressin Receptor	Cardiovascular Disease Endocrinology
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K_i vaule of 1.4 nM .

HY-130250

SR-4835 15+ Cited Publications	CDK Apoptosis	Cancer
SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC₅₀=99 nM, K_d=98 nM; CDK13: K_d=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death .

HY-14137

Rimonabant Hydrochloride 10+ Cited Publications SR 141716A Hydrochloride	Cannabinoid Receptor Bacterial	Infection Metabolic Disease Cancer
Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an K_i of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-13767

Tirapazamine 10+ Cited Publications SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone	DNA/RNA Synthesis	Cancer
Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells .

HY-13439

SR144528 5+ Cited Publications	Cannabinoid Receptor	Neurological Disease
SR144528 is a potent and selective CB2 receptor antagonist with a K_i of 0.6 nM.

HY-117516

SR10067	REV-ERB	Neurological Disease Metabolic Disease
SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC₅₀ values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders .

HY-107413

SR11237 BMS-649	RAR/RXR Tyrosine Hydroxylase	Cancer
SR11237 (BMS-649) GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

HY-111400

SR-4370	HDAC	Cancer
SR-4370 is an inhibitor of HDAC, with IC₅₀s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

HY-136530

SR18662	KLF	Cancer
SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC₅₀ of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer .

HY-16972

SR9243 5+ Cited Publications	LXR	Cancer
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.

HY-107664

SR 142948	Neurotensin Receptor	Neurological Disease
SR 142948 is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC₅₀s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders .

HY-B0209

Metolazone 2 Publications Verification SR-720-22	Thrombin	Cardiovascular Disease
Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.

HY-101491

SR-18292 60+ Cited Publications	PGC-1α Autophagy	Metabolic Disease
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.

HY-111454

SR17018 1 Publications Verification	Opioid Receptor	Neurological Disease
SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC₅₀ of 97 nM.

HY-145409

SR-0813	Epigenetic Reader Domain	Cancer
SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC₅₀ and EC₅₀ values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC₅₀ and EC₅₀ values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (K_d=3.5 μM) than ENL YEATS (K_d=30 nM). SR-0813 can be used for the research of acute leukemia .

HY-101454

SR0987 3 Publications Verification	ROR	Inflammation/Immunology Cancer
SR0987, a SR1078 analog, is a RORγt agonist, with an EC₅₀ of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1 .

HY-123936

SR12343	NF-κB IKK COX Interleukin Related	Neurological Disease Inflammation/Immunology
SR12343 is a IKK/NF-κB inhibitor and a mimetic of the NF-κB essential modulator (NEMO)-binding domain (NBD). SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 extends the healthspan of naturally aged and accelerated aging mice. SR12343 can be used for research on inflammatory and degenerative diseases .

HY-131454A

SR-717 free acid 25+ Cited Publications	STING	Inflammation/Immunology Cancer
SR-717 free acid is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

HY-100011

SR-3029 2 Publications Verification	Casein Kinase	Cancer
SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC₅₀s of 44 nM and 260 nM, respectively, and K_is of 97 nM for both kinases.

HY-12483

SR1664	PPAR	Metabolic Disease
SR1664 is a PPARγ antagonist. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC₅₀=80 nM; K_i= 28.67 nM) .

HY-112247

SR 16832	PPAR TGF-beta/Smad	Metabolic Disease Inflammation/Immunology
SR 16832 is a dual-site covalent, orthosteric and allosteric PPARγ antagonist. SR 16832 activates the TGF-β signaling pathway and upregulates the expression of Vimentin and Fibronectin (Fibronectin). SR 16832 is toxic to bronchial epithelium. SR 16832 can be used in research related to type 2 diabetes and pulmonary fibrosis .

HY-100277

Mifobate 1 Publications Verification SR-202	PPAR	Metabolic Disease
Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC₅₀=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects .

HY-13300

SR-3677 1 Publications Verification	ROCK Autophagy	Cancer
SR-3677 is a potent and selective ROCK-II inhibitor with an IC₅₀ of ~3 nM.

HY-11077

SR 146131	Cholecystokinin Receptor	Metabolic Disease Endocrinology
SR 146131 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.

HY-124767

SR 142948A	Neuropeptide Y Receptor	Neurological Disease
SR 142948A is a non-peptide neuropeptide neuropeptin (NT) receptor antagonist. SR 142948A is able to bind to neuropeptin receptors, especially with high affinity for NT1 and NT2 receptors. SR 142948A is mainly used to study the role of neuropeptide in the neurotransmitter system, especially the dopamine system .

HY-148103

SR12418	REV-ERB	Inflammation/Immunology
SR12418 is a REV-ERB-specific synthetic ligand with IC₅₀s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research .

HY-19353

SR7826 1 Publications Verification	LIM Kinase (LIMK)	Neurological Disease Cancer
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC₅₀ of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases .

HY-115881

SR-1114	PROTACs Epigenetic Reader Domain	Cancer
SR-1114 is a PROTAC degrader targeting ENL. SR-1114 degrades ENL in a CRBN-dependent manner and selectively downregulates ENL target genes. SR-1114 can promote the differentiation of acute myeloid leukemia cells. SR-1114 can be used in tumor research. (Pink: ENL ligand (HY-145409); Black: Linker; Blue: E3 Ligand (HY-14658)) .

HY-135674

SR-318 1 Publications Verification	p38 MAPK TNF Receptor	Inflammation/Immunology Cancer
SR-318, a chemical probe, is a potent and highly selective p38 MAPK inhibitor with IC₅₀s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC₅₀ of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity .

HY-12829

SR-3306 1 Publications Verification	JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor. SR-3306 is a neuroprotective agent that can be used for the study of Parkinson's disease, ischemia/reperfusion (I/R) injury and obesity .

HY-136909

SR33805	Calcium Channel	Cardiovascular Disease
SR33805 is a potent Ca ²⁺ channel antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca ²⁺ channels. SR33805 can be used for the research of acute or chronic failing hearts .

HY-13751

SR-31747	Sigma Receptor	Inflammation/Immunology
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .

HY-111953

SR-4559	MAGL ATGL	Metabolic Disease
SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research .

HY-167208

SR-302	Discoidin Domain Receptor p38 MAPK	Inflammation/Immunology Cancer
SR-302, a chemical probe, is a potent and selectivity DDR/p38 inhibitor, with IC₅₀ values of 0.125, 0.023 and 0.018 μM for p38α, DDR1 and DDR2, respectively. SR-302 can be used for the research of fibrotic disorders, such as renal and pulmonary fibrosis, atherosclerosis, and various forms of cancer .

HY-116972

Etanidazole SR 2508	Biochemical Assay Reagents	Cancer
Etanidazole (SR 2508), a 2-nitroimidazole compound, is a hypoxic radiosensitizer used in cancer diagnosis and chemotherapy research .

HY-108907

SR-1277	Casein Kinase	Cancer
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC₅₀s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC₅₀s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer .

HY-107596

SR-3576	JNK	Others
SR-3576 is a highly potent and selective JNK3 inhibitor with an IC₅₀ of 7 nM .

HY-118961

SR31527 chloride	Kinesin	Cancer
SR31527 chloride is a potent KIFC1 inhibitor with an IC₅₀ value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation .

HY-120785

SR1555	ROR	Inflammation/Immunology
SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC₅₀ value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases .

HY-138007

SR-1903	ROR PPAR LXR	Metabolic Disease Inflammation/Immunology
SR-1903 is an inverse agonist of RORγ and PPARγ (IC₅₀ of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a LXR agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models .

HY-107664A

SR 142948 dihydrochloride	Neurotensin Receptor	Neurological Disease
SR 142948 dihydrochloride is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC₅₀s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 dihydrochloride antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC₅₀ of 3.9 nM. SR 142948 dihydrochloride blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 dihydrochloride shows blood-brain permeability and can be used in study of psychiatric disorders .

HY-120696

SR9186 ML368	Cytochrome P450 Parasite	Infection Cancer
SR9186 (ML368) is a selective CYP3A4 inhibitor with IC₅₀ values of 9, 4, and 38 nM for Midazolam → 1'-hydroxymidazolam, Testosterone → 6β-hydroxytestosterone, and Vincristine → Vincristine M1, respectively. SR-9186 inhibits the development of hepatic-stage P. falciparum and blocks ivermectin metabolism. SR-9186 can be used in breast cancer research .

HY-107610

SR2640 hydrochloride	Leukotriene Receptor	Inflammation/Immunology
SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma .

HY-149292

SR-4133	Casein Kinase	Cancer
SR-4133 is a potent and highly CK1ε selective inhibitor with an IC₅₀ of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1 .

HY-122681

SR-16434 SR-16435 free base	Opioid Receptor	Neurological Disease
SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor K_i=7.49; μ-Opioid receptor K_i=2.70). SR-16434 can relieve pain .

HY-100011R

SR-3029 (Standard)	Casein Kinase Reference Standards	Cancer
SR-3029 (Standard) is the analytical standard of SR-3029 (HY-100011). This product is intended for research and analytical applications. SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13434

Ionomycin 115+ Cited Publications SQ23377	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium 115+ Cited Publications SQ23377 calcium	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-201672

*18:1 BMP (S,R) ammonium*	Lipid	Biochemical Assay Reagents
18:1 BMP (S,R) ammonium is a bis(monoacylglycero)phosphate (BMP) .

HY-N15968

*14:0 Hemi BMP (S,R) ammonium*	Lipid	Biochemical Assay Reagents
14:0 Hemi BMP (S,R) ammonium is a bis(monoacylglycero)phosphate (BMP).

Cat. No.	Product Name	Chemical Structure

HY-12753S1

Debutyldronedarone-d6 hydrochloride
Debutyldronedarone-d₆ (hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent .

HY-141749S

(Rac)-Clopidogrel carboxylic acid-d4
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid .

HY-14136S

Rimonabant-d10
Rimonabant-d₁₀ is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-B0202S

Irbesartan-d4

Irbesartan-d₄ (SR-47436-d₄) is the deuterium labeled Irbesartan Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

HY-14137S

Rimonabant-d10 hydrochloride
Rimonabant-d₁₀ (hydrochloride) is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an K_i of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3) .

HY-101491S

SR-18292-d9
SR-18292-d₉ is the deuterium labeled SR-18292 (HY-101491). SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes .

HY-B0209S

Metolazone-d7
Metolazone-d₇ is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.

HY-A0016S3

Dronedarone-d6

Dronedarone-d₆ (SR 33589-d₆) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 .

HY-B0202AS

Irbesartan-d7 hydrochloride

Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202S4

Irbesartan-13C,d4
Irbesartan- ¹³C,d₄ (SR-47436- ¹³C,d₄; BMS-186295- ¹³C,d₄) is ¹³C-labeled Irbesartan (HY-B0202) .

HY-12753AS

Debutyldronedarone-d7 hydrochloride

Debutyldronedarone-d₇ hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

HY-B0202S2

Irbesartan-d6-1
Irbesartan-d₆-1 is the deuterium labeled Irbesartan . Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-12753S

Debutyldronedarone-d7
Debutyldronedarone-d₇ is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans.Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent .

HY-141749AS

Clopidogrel carboxylic acid-d4
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-12772S4

(2S)-Hydroxy Itraconazole-d8
(2S)-Hydroxy Itraconazole-d8 ((2S)-R-63373-d8) is the enantiomer of Hydroxy Itraconazole-d8 (R-63373-d8) (HY-12772S). Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-169898S

SR 144528-d3
SR 144528-d₃ is deuterium labeled SR 144528 .

Targets Recommended: Serine Racemase (SR) CaSR Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107413G

SR11237	RAR/RXR Tyrosine Hydroxylase	Neurological Disease Inflammation/Immunology
SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

HY-15001G

Stemregenin 1 SR1	Aryl Hydrocarbon Receptor	Cancer
Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC₅₀ of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases .

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