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Cat. No.: HY-181961

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SR-THAP

SR-THAP is a γ-aminobutyric acid transporter 3 (GAT3) inhibitor with an IC₅₀ of 4.9 μM, and exhibits 42-fold and 23-fold selectivity over GAT1 and GlyT1, respectively. SR-THAP inhibits GABA uptake in mammalian cells. SR-THAP is applicable to the research of epilepsy, Alzheimer's disease and ischemic stroke.

For research use only. We do not sell to patients.

CAS No.: 3098361-74-8
Formula: C₃₁H₃₅NO₆
Molecular Weight:517.61

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Please store the product under the recommended conditions in the Certificate of Analysis.

SR-THAP Chemical Structure

CAS No.: 3098361-74-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

SR-THAP (0-1000 μM; 120 min preincubation + 3 min uptake) inhibits hGAT3^C316S mutant-mediated [³H]GABA uptake in HEK293T cells with reduced potency (IC₅₀ = 10.6 μM) compared to wild-type hGAT3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3098361-74-8
Molecular Weight 517.61
Formula C₃₁H₃₅NO₆
SMILES

COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)/C=C/CN4CCC[C@]4([H])[C@@H](C(O)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mortensen JS, et al. Structural basis for selective inhibition of human GABA transporter GAT3. Nat Commun. 2026;17(1):1774. Published 2026 Jan 29. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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