2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. SR-THAP

SR-THAP is a γ-aminobutyric acid transporter 3 (GAT3) inhibitor with an IC50 of 4.9 μM, and exhibits 42-fold and 23-fold selectivity over GAT1 and GlyT1, respectively. SR-THAP inhibits GABA uptake in mammalian cells. SR-THAP is applicable to the research of epilepsy, Alzheimer's disease and ischemic stroke.

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SR-THAP

SR-THAP Chemical Structure

CAS No. : 3098361-74-8

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SR-THAP Related Antibodies

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Description

SR-THAP is a γ-aminobutyric acid transporter 3 (GAT3) inhibitor with an IC50 of 4.9 μM, and exhibits 42-fold and 23-fold selectivity over GAT1 and GlyT1, respectively. SR-THAP inhibits GABA uptake in mammalian cells. SR-THAP is applicable to the research of epilepsy, Alzheimer's disease and ischemic stroke[1].

In Vitro

SR-THAP (0-1000 μM; 120 min preincubation + 3 min uptake) inhibits hGAT3C316S mutant-mediated [3H]GABA uptake in HEK293T cells with reduced potency (IC50 = 10.6 μM) compared to wild-type hGAT3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR-THAP Related Antibodies
Molecular Weight

517.61

Formula

C31H35NO6
CAS No.
SMILES

COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)/C=C/CN4CCC[C@]4([H])[C@@H](C(O)=O)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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SR-THAP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-THAP3098361-74-8GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptormammalian cellsHEK293T cellsepilepsyalzheimer’s diseasehGAT1hGAT3hGlyT1human GABA transporter 3ischemic strokeGABAInhibitorinhibitorinhibit

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