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  3. SR121566A

SR121566A 

Cat. No.: HY-U00235
Handling Instructions

SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.

For research use only. We do not sell to patients.

SR121566A Chemical Structure

SR121566A Chemical Structure

CAS No. : 180144-61-0

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Description

SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.

IC50 & Target

GP IIb-IIIa[1]

In Vivo

SR121566A leads to dose-dependent increases in TTO, a statistically significant increase being observed at the doses of 0.3 mg/kg (473%) and 30 mg/kg (771%), respectively[2].

Molecular Weight

431.51

Formula

C₂₀H₂₅N₅O₄S

CAS No.

180144-61-0

SMILES

O=C(O)CN1CCC(N(C2=NC(C3=CC=C(C(N)=N)C=C3)=CS2)CCC(O)=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[2]

Male mice (26-30 g) are anesthetized, artificially ventilated, and placed on a heated jacket to control body temperature. A femoral vein is cannulated for i.v. injections. In thrombosis experiments, drugs including SR121566A are administered in 0.9% saline for intravenous studies (0.1 mL/30 g, 5 min before stimulation) and in water for oral studies (0.1 mL/30 g, 120 min before stimulation)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

SR121566AIntegrinInhibitorinhibitorinhibit

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