Novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet aggregation inhibitors

  • Eur J Med Chem. 2007 Aug;42(8):1144-50. doi: 10.1016/j.ejmech.2007.01.016.
Umadevi Bhoga  1
Affiliations
  • 1. Organic Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India. [email protected]
PMID: 17350143 DOI: 10.1016/j.ejmech.2007.01.016
Abstract

A novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41, a mesoporous aluminosilicate catalyst and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compounds N-(2'-flourophenyl)-4-(3-pyridyl)thiazol-2-amine (9e) was found to be the most potent, IC(50)=4.84x10(-7)M.