C105SR
Based on 1 Customer Validation
C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model.
For research use only. We do not sell to patients.
- Purity: 99.49%
- Formula: C32H33BrN4O3S
- Molecular Weight:633.60
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
Caspase 3 |
Caspase-7 |
Cyclophilin D 5 nM (IC50) |
C105SR (0.5/1/5/10/50/100 μM) inhibit CypD PPIase activity in Mitochondria[1].
C105SR (1μM, 4 h for hypoxia (1% O2) plus 1 h for reoxygenation (21% O2)) prevent mPTP opening [1].
C105SR (0.5/1/5/10/50/100 μM, 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)) reducing hypoxia/reoxygenation-induced cell death in AML-12 cell[1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML-12 cell
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Concentration:0.5/1/10/50/100 μM
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Incubation Time:4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)
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Result:Reduced LDH release and increased cell viability by approximatively 75% at 0.5μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hepatic IRI model [1]
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Dosage:50 mg/kg
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Administration:Subcutaneous injection (s.c.)
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Result:Protected mouse livers against the effects of ischaemia and reperfusion.
Chemical Information
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Appearance Solid
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Molecular Weight 633.60
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Formula C32H33BrN4O3S
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Color White to light yellow
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SMILES
O=C([C@@H](NC(NCC1=CC2=C(NCCC2)C=C1)=O)C3=CC(Br)=CC=C3OC)N4[C@@H](C5=C6C(C=CS6)=CC=C5)CCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (394.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5783 mL | 7.8914 mL | 15.7828 mL | 39.4571 mL |
| 5 mM | 0.3157 mL | 1.5783 mL | 3.1566 mL | 7.8914 mL | |
| 10 mM | 0.1578 mL | 0.7891 mL | 1.5783 mL | 3.9457 mL | |
| 15 mM | 0.1052 mL | 0.5261 mL | 1.0522 mL | 2.6305 mL | |
| 20 mM | 0.0789 mL | 0.3946 mL | 0.7891 mL | 1.9729 mL | |
| 25 mM | 0.0631 mL | 0.3157 mL | 0.6313 mL | 1.5783 mL | |
| 30 mM | 0.0526 mL | 0.2630 mL | 0.5261 mL | 1.3152 mL | |
| 40 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9864 mL | |
| 50 mM | 0.0316 mL | 0.1578 mL | 0.3157 mL | 0.7891 mL | |
| 60 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6576 mL | |
| 80 mM | 0.0197 mL | 0.0986 mL | 0.1973 mL | 0.4932 mL | |
| 100 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3946 mL |
C105SR Related Classifications
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