SR-BI/SCARB1 Protein, Mouse (HEK293, His)
The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells. Both isoform 1 and isoform 2 act as high-density lipoprotein (HDL) receptors, promoting cholesterol ether uptake and HDL-dependent cholesterol efflux. SR-BI/SCARB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells. Both isoform 1 and isoform 2 act as high-density lipoprotein (HDL) receptors, promoting cholesterol ether uptake and HDL-dependent cholesterol efflux. SR-BI/SCARB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-His labeled tag.
Background
SR-BI/SCARB1 functions as a versatile receptor with binding capabilities for various ligands, including phospholipids, cholesterol ester, lipoproteins, phosphatidylserine, and apoptotic cells. Both isoform 1 and isoform 2 serve as receptors for high-density lipoprotein (HDL), mediating the selective uptake of cholesteryl ether and facilitating HDL-dependent cholesterol efflux. Additionally, SR-BI/SCARB1 plays a role in the transport of free and esterified cholesterol between the cell surface and apolipoprotein B (apoB)-containing lipoproteins, as well as modified lipoproteins, albeit less efficiently than HDL. The receptor may also participate in the phagocytosis of apoptotic cells through its phosphatidylserine binding activity. Notably, the C-terminal region of SR-BI/SCARB1 interacts with PDZK1, highlighting its potential involvement in complex cellular processes and signaling pathways.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-His
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Accession
Q61009/NP_058021.1 (P33-V440)
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Molecular Construction
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N-term
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SR-BI (P33-V440)
Accession # Q61009/NP_058021.1 -
His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
SCARB1; CD36 And LIMPII Analogous 1; Prev. CD36L1; Scavenger Receptor Class B, Member 1; SR-BI; Scavenger Receptor Class B Type III; CLA-1; CD36 Antigen-Like 1; SRB1; CD36 Antigen; CLA1; HDLQTL6; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Rece
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AA Sequence
PSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQV
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Predicted Molecular Mass
47 kDa
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Molecular Weight
Approximately 70-90 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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