Scarb1 - scavenger receptor class B, member 1 Gene

Also Known as CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Chohd1; Hlb398; mSR-BI; D5Ertd460e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20778

Summary

Enables amyloid-beta binding activity; Apolipoprotein binding activity; and high-density lipoprotein particle binding activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of lipid metabolic process. Acts upstream of or within several processes, including blood vessel endothelial cell migration; Cholesterol catabolic process; and endothelial cell proliferation. Located in caveola; cell surface; and cytoplasm. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; hemolymphoid system gland; and reproductive system. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Scarb1 Products (3)

mRNA Protein Name
NM_001205082.1 NP_001192011.1 scavenger receptor class B member 1 isoform 2
NM_001205083.1 NP_001192012.1 scavenger receptor class B member 1 isoform 3
NM_016741.2 NP_058021.1 scavenger receptor class B member 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amyloid-beta binding IGI
IGI: Inferred from genetic interaction
11240025 MGI
enables apolipoprotein binding IPI
IPI: Inferred from physical interaction
9254056 MGI
enables high-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
14729860 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
16339487 MGI
acts upstream of or within cholesterol catabolic process IDA
IDA: Inferred from direct assay
11278646 MGI
acts upstream of or within cholesterol catabolic process IMP
IMP: Inferred from mutant phenotype
10559220 MGI
involved in cholesterol efflux IDA
IDA: Inferred from direct assay
14718538 MGI
involved in cholesterol efflux IMP
IMP: Inferred from mutant phenotype
21481393 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
19136670 MGI
involved in cholesterol import IDA
IDA: Inferred from direct assay
14718538 MGI
involved in cholesterol import IMP
IMP: Inferred from mutant phenotype
18175806 MGI
acts upstream of or within cholesterol transport IDA
IDA: Inferred from direct assay
8753864 MGI
acts upstream of or within cholesterol transport IMP
IMP: Inferred from mutant phenotype
10559220 MGI
acts upstream of or within endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16339487 MGI
involved in high-density lipoprotein particle remodeling IMP
IMP: Inferred from mutant phenotype
15210842 MGI
acts upstream of or within intestinal lipid absorption IMP
IMP: Inferred from mutant phenotype
25701869 MGI
involved in low-density lipoprotein particle clearance IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in phospholipid transport IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in regulation of phosphatidylcholine catabolic process IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in reverse cholesterol transport IMP
IMP: Inferred from mutant phenotype
19136670 MGI
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
19136670 MGI
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
9148942 MGI
located in cell surface IDA
IDA: Inferred from direct assay
21481393 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21481393 MGI
located in membrane IDA
IDA: Inferred from direct assay
9148942 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9148942 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

scavenger receptor class B member 1

  • HDL QTL 1

  • scavenger receptor class B type I

  • scavenger receptor class B1

Recombinant Scarb1 Proteins

Cat. No. Product Name Accession Purity
HY-P76086 SR-BI/SCARB1 Protein, Mouse (HEK293, His-Fc) Q61009 (P33-V440) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76087 SR-BI/SCARB1 Protein, Mouse (HEK293, His) Q61009/NP_058021.1 (P33-V440) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18098 Scarb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12488 SCARB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24572 Scarb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scarb1 NCBI NCBI:949