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  4. Kibdelone C

Kibdelone C is a hexacyclic tetrahydroxanthone natural product and anticancer agent with sub-nanomolar GI50 activity against human SR leukemia and SN12C renal carcinoma cell lines. Kibdelone C disrupts the actin cytoskeleton in human cancer cells, leading to cell contraction and actin stress fiber formation, without direct actin binding, actin polymerization effects, topoisomerase I/II inhibition, or DNA binding. Kibdelone C can be used for the research of leukemia, and renal cell carcinoma.

For research use only. We do not sell to patients.

Kibdelone C

Kibdelone C Chemical Structure

CAS No. : 934464-79-6

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Kibdelone C Related Antibodies

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Description

Kibdelone C is a hexacyclic tetrahydroxanthone natural product and anticancer agent with sub-nanomolar GI50 activity against human SR leukemia and SN12C renal carcinoma cell lines. Kibdelone C disrupts the actin cytoskeleton in human cancer cells, leading to cell contraction and actin stress fiber formation, without direct actin binding, actin polymerization effects, topoisomerase I/II inhibition, or DNA binding. Kibdelone C can be used for the research of leukemia, and renal cell carcinoma[1][2].

In Vitro

Kibdelone C (10-100 nM) does not directly interact with actin or affect its in vitro polymerization, even at concentrations up to 100 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kibdelone C Related Antibodies
Molecular Weight

585.99

Formula

C29H28ClNO10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C2C3=C(O)C(C(N(C(CCC)=C4Cl)C)=O)=C4C(O)=C3CCC2=C(C5=C1C(C6=C([C@H](C[C@@H]([C@@H]6O)O)O)O5)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.4%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References
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Kibdelone C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kibdelone C934464-79-6Drug DerivativeDrug derivativehuman SR leukemia cell linesSN12C renal carcinoma cell linesHCT116 human colon cancer cellsH2122 human non-small cell lung cancer cellsHeLa human cervical cancer cellsrenal cell carcinomaleukemiaH157 human non-small cell lung cancer cellsH2073 human non-small cell lung cancer cellsactin cytoskeletonInhibitorinhibitorinhibit

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