934464-79-6
Chemical Structure
Kibdelone C
- CAS No.: 934464-79-6
- Formula:C29H28ClNO10
- Molecular Weight:585.99
IUPAC Name: (10S,12S,13R)-4-chloro-5,10,12,13,15,16-hexahydroxy-8-methoxy-2-methyl-3-propyl-6,7,10,11,12,13-hexahydro-2H-chromeno[2',3':6,7]naphtho[2,1-g]isoquinoline-1,14-dione
InChIKey: NEZGGHIIKFHZCZ-MZFXBISCSA-N
SMILES: OC1=C2C3=C(O)C(C(N(C(CCC)=C4Cl)C)=O)=C4C(O)=C3CCC2=C(C5=C1C(C6=C([C@H](C[C@@H]([C@@H]6O)O)O)O5)=O)OC
Biological Activity: Kibdelone C is a hexacyclic tetrahydroxanthone natural product and anticancer agent with sub-nanomolar GI50 activity against human SR leukemia and SN12C renal carcinoma cell lines. Kibdelone C disrupts the actin cytoskeleton in human cancer cells, leading to cell contraction and actin stress fiber formation, without direct actin binding, actin polymerization effects, topoisomerase I/II inhibition, or DNA binding. Kibdelone C can be used for the research of leukemia, and renal cell carcinoma[1][2].
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Kibdelone C | Kibdelone C is a hexacyclic tetrahydroxanthone natural product and anticancer agent with sub-nanomolar GI50 activity against human SR leukemia and SN12C renal carcinoma cell lines. Kibdelone C disrupts the actin cytoskeleton in human cancer cells, leading to cell contraction and actin stress fiber formation, without direct actin binding, actin polymerization effects, topoisomerase I/II inhibition, or DNA binding. Kibdelone C can be used for the research of leukemia, and renal cell carcinoma. | |||||||||||||||||||||
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- [1]. Sloman DL, et al. Total synthesis and absolute stereochemical assignment of kibdelone C. J Am Chem Soc. 2011;133(26):9952-9955. [Content Brief]
- [2]. Rujirawanich J, et al. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives. J Am Chem Soc. 2016;138(33):10561-10570. [Content Brief]
Keywords
