SCARB1 Antibody (YA1908)(PBS only)
(Synonyms: CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; Scavenging Receptor SR-BI)SCARB1 Antibody (YA1908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCARB1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
SCARB1 Antibody (YA1908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCARB1.
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Host Rabbit
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 61 kDa
Recombinant protein of human Scavenging Receptor SR-BI
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Verification Images
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Western blot analysis of extracts from HepG2 (lane 2(20μg), Hela (lane 3(20μg) and NIH3T3 (lane 4(20μg) using SCARB1 (HY-P82163) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Background
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Function
SCARB1 receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate; (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus; (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding[1][2][3][4][5][6][7].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Membrane, caveola; Multi-pass membrane protein
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Expression
Tissue_specificity:Broad expression -
Isoforms & Post-Translational Modification
Q8WTV0 has 5 isomers: Q8WTV0-1: 60878 Da (predicted); Q8WTV0-2: 56973 Da (predicted); Q8WTV0-3: 45103 Da (predicted); Q8WTV0-4: 53579 Da (predicted); Q8WTV0-5: 56170 Da (predicted).
N-glycosylated;The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds -
Subunit
The C-terminal region binds to PDZK1
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SwissProt ID
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Synonyms
CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; Scavenging Receptor SR-BI
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Research Field
Microbiology
Documentation
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