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SCARB1 Antibody (YA1908)

(Synonyms: CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; Scavenging Receptor SR-BI)
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Based on 1 Customer Validation

SCARB1 Antibody (YA1908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCARB1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IP

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for SCARB1 Antibody (YA1908)
  • SCARB1 Antibody (YA1908) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:20

Product Details

Description

SCARB1 Antibody (YA1908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCARB1.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 80 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 61 kDa
Species Reactivity Database
Immunogen

Recombinant protein of human Scavenging Receptor SR-BI

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3104276

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for SCARB1 Antibody (YA1908)
    Western blot analysis of extracts from HepG2 (lane 2(20μg), Hela (lane 3(20μg) and NIH3T3 (lane 4(20μg) using SCARB1 (HY-P82163) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    SCARB1 receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate; (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus; (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding[1][2][3][4][5][6][7].

  • Subcellular Localization

    Cell membrane; Multi-pass membrane protein; Membrane, caveola; Multi-pass membrane protein

  • Expression


    Tissue_specificity:Broad expression

  • Isoforms & Post-Translational Modification

    Q8WTV0 has 5 isomers: Q8WTV0-1: 60878 Da (predicted); Q8WTV0-2: 56973 Da (predicted); Q8WTV0-3: 45103 Da (predicted); Q8WTV0-4: 53579 Da (predicted); Q8WTV0-5: 56170 Da (predicted).
    N-glycosylated;The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds

  • Subunit

    The C-terminal region binds to PDZK1

  • SwissProt ID

    Q8WTV0

  • Gene ID
    949 [NCBI]
  • Synonyms

    CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; Scavenging Receptor SR-BI

  • Research Field

    Microbiology

SCARB1 Antibody (YA1908) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from HepG2 (lane 2(20μg), Hela (lane 3(20μg) and NIH3T3 (lane 4(20μg) using SCARB1 (HY-P82163) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • SCARB1 Antibody (YA1908) Product Image
    1/16
  • Experimental Validation Results for SCARB1 Antibody (YA1908)
  • SCARB1 Antibody (YA1908) Product Image
  • Experimental Validation Results for SCARB1 Antibody (YA1908)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from HepG2 (lane 2(20μg), Hela (lane 3(20μg) and NIH3T3 (lane 4(20μg) using SCARB1 (HY-P82163) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for SCARB1 Antibody (YA1908)
  • SCARB1 Antibody (YA1908) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from HepG2 (lane 2(20μg), Hela (lane 3(20μg) and NIH3T3 (lane 4(20μg) using SCARB1 (HY-P82163) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • SCARB1 Antibody (YA1908) Product Image WB