SCARB1 Antibody (YA4384)
(Synonyms: CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6)SCARB1 Antibody (YA4384) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SCARB1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
SCARB1 Antibody (YA4384) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SCARB1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 61 kDa
Purified recombinant fragment of human SCARB1 (AA: Extra(33-232)) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SCARB1 receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate; (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus; (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding[1][2][3][4][5][6][7].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Membrane, caveola; Multi-pass membrane protein
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Expression
Tissue_specificity:Broad expression -
Isoforms & Post-Translational Modification
Q8WTV0 has 5 isomers: Q8WTV0-1: 60878 Da (predicted); Q8WTV0-2: 56973 Da (predicted); Q8WTV0-3: 45103 Da (predicted); Q8WTV0-4: 53579 Da (predicted); Q8WTV0-5: 56170 Da (predicted).
N-glycosylated;The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds -
Subunit
The C-terminal region binds to PDZK1
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SwissProt ID
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Synonyms
CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
Documentation
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