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ZFYVE1 Antibody (YA8789)(PBS only)

(Synonyms: DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1)

ZFYVE1 Antibody (YA8789) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFYVE1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ZFYVE1 Antibody (YA8789)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-800

Product Details

Description

ZFYVE1 Antibody (YA8789) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFYVE1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 40.1 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-308 of human ZFYVE1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ZFYVE1 plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. Regulates the morphology, size and distribution of LDs. Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger |(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication[1][2][3][4].

  • Subcellular Localization

    Golgi apparatus, Golgi stack,Golgi apparatus,Endoplasmic reticulum,Lipid droplet,Preautophagosomal structure,Mitochondrion

  • Expression


    Tissue_Specificity: Highly expressed in heart. Also detected in the testis|Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart

  • Isoforms & Post-Translational Modification

    Q9HBF4 has three isomers: Q9HBF4-1: 87176 Da (predicted); Q9HBF4-2: 40260 Da (predicted); Q9HBF4-3: 85592 Da (predicted).

  • Subunit

    Interacts with RAB18 (in GTP-bound form) (PubMed:30970241, PubMed:31293035)

  • SwissProt ID

    Q9HBF4

  • Synonyms

    DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1

ZFYVE1 Antibody (YA8789)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • ZFYVE1 Antibody (YA8789)(PBS only) Product Image