2. Metabolic Enzyme/Protease Anti-infection
  3. Cytochrome P450 Parasite
  4. SR9186

SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism.

For research use only. We do not sell to patients.

SR9186 Chemical Structure

SR9186 Chemical Structure

CAS No. : 1361414-26-7

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1 mg USD 410 In-stock
5 mg USD 1230 In-stock
10 mg USD 1950 In-stock
25 mg USD 3700 In-stock
50 mg USD 5900 In-stock
100 mg USD 9450 In-stock
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Based on 1 publication(s) in Google Scholar

SR9186 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

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Description

SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism[1].

IC50 & Target

Plasmodium

 

CYP3

 

Molecular Weight

430.46

Formula

C26H18N6O
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C(NC1=CC=C(C2=C3C(NC=N3)=NC=C2)C=C1)NC4=CC=C(C5=CC=C(C#N)C=C5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (72.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3231 mL 11.6155 mL 23.2310 mL
5 mM 0.4646 mL 2.3231 mL 4.6462 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3231 mL 11.6155 mL 23.2310 mL 58.0774 mL
5 mM 0.4646 mL 2.3231 mL 4.6462 mL 11.6155 mL
10 mM 0.2323 mL 1.1615 mL 2.3231 mL 5.8077 mL
15 mM 0.1549 mL 0.7744 mL 1.5487 mL 3.8718 mL
20 mM 0.1162 mL 0.5808 mL 1.1615 mL 2.9039 mL
25 mM 0.0929 mL 0.4646 mL 0.9292 mL 2.3231 mL
30 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9359 mL
40 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.4519 mL
50 mM 0.0465 mL 0.2323 mL 0.4646 mL 1.1615 mL
60 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9680 mL
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SR9186 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR91861361414-26-7ML368SR 9186SR-9186ML 368ML-368Cytochrome P450ParasiteCYPsCYP3A4 inhibitorliver-stageP. falciparumivermectin metabolismInhibitorinhibitorinhibit

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