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Foropafant (Synonyms: SR27417)

Cat. No.: HY-128694
Handling Instructions

Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets.

For research use only. We do not sell to patients.

Foropafant Chemical Structure

Foropafant Chemical Structure

CAS No. : 136468-36-5

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Description

Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].

IC50 & Target

Ki: 57 pM ([3H]PAF binding)[1]

Molecular Weight

464.72

Formula

C₂₈H₄₀N₄S

CAS No.

136468-36-5

SMILES

CC(C)C1=CC(C(C)C)=C(C2=CSC(=N2)N(CCN(C)C)CC2=CC=CN=C2)C(=C1)C(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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