136468-36-5
Chemical Structure
Foropafant
Synonym(s): SR27417
- CAS No.: 136468-36-5
- Formula:C28H40N4S
- Molecular Weight:464.72
IUPAC Name: N1,N1-dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-diamine
InChIKey: VVBFISAUNSXQGZ-UHFFFAOYSA-N
SMILES: CC(C)C1=CC(C(C)C)=C(C2=CSC(=N2)N(CCN(C)C)CC2=CC=CN=C2)C(=C1)C(C)C
Biological Activity: Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Foropafant | 99.97% | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets. | ||||||||||||||||||||
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